This book is an excellent, up-to-date reference on a relatively
young area of research in which virology, cellular biology and
molecular pathogenesis govern the principles of coinvestigation.
Thus, the book will be of great interest to virologists, molecular
immunologists and biologists, and biochemists but also to clinical
pharmacologists in the long-term search for new antiviral agents.
Ulrich Desselberger, Gif-sur-Yvette/Cambridge.
Infection of a naive (non-immune) host with a virus elicits an
immediate response which results in a cascade of changes in the
host, including an interferon response (innate immunity). The
outcome of this interaction is influenced by the genes of the virus
as well as the genes of the host. Interestingly, different viruses
do it in different ways. Not only is there a plethora of mechanisms
used by the invading organisms, but the host has also evolved a
great variety of redundant and robust countermeasures. This
interplay of host and virus represents one of the most significant
frontiers in biology today. A clearer understanding of the
mechanisms involved will arm us with better strategies to deal with
viruses, including emerging pathogens and potential bioterrorism
agents. This book is sure to benefit students, scientists, and
physicians working in the areas of virology, immunology,
microbiology, and infectious diseases. Pharmaceutical industry
professionals will also find interest in this illuminating look
into virus/host interactions."
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