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Cap-Independent Translation (Paperback, Softcover reprint of the original 1st ed. 1995) Loot Price: R2,992
Discovery Miles 29 920
Cap-Independent Translation (Paperback, Softcover reprint of the original 1st ed. 1995): Peter Sarnow

Cap-Independent Translation (Paperback, Softcover reprint of the original 1st ed. 1995)

Peter Sarnow

Series: Current Topics in Microbiology and Immunology, 203

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Loot Price R2,992 Discovery Miles 29 920 | Repayment Terms: R280 pm x 12*

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Whether or not an mRNA is translated is often thought to be a simple function of its steady-state concentration and the ab- sence of inhibitory proteins or RNA structures in the 5' and 3' noncoding regions. The articles presented in this volume show an unexpected flexibility of the eukaryotic translational appara- tus in the mechanism of translational initiation and provide new opportunities for regulation. Most or all mRNA molecules synthesized by RNA poly- 7 merase II in eukaryotic cells contain a 5' terminal mGpppG dinucleotide, also known as the "cap structure. " RNAs carrying a cap structure have been shown to be more resistant to attack by exoribonucleases than their uncapped counterparts. Further- more, the cap facilitates transport of the RNAs from the nucleus to the cytoplasm. In the cytoplasm, the cap functions as a binding site for the cap binding protein complex eIF-4, which enhances the translation of the RNAs by the eukaryotic trans- lational apparatus. Specifically, it has been postulated that bind- ing of e1F-4 to the 5' terminal cap facilitates the recruitment of ribosomal subunits onto the mRNAs via their free 5' ends (cap- dependent translation). Accordingly, uncapped RNAs are generally translated more poorly than capped RNAs. However, during the past 6 years both viral and cellular mRNAs have been discovered that can be translated cap-independently.

General

Imprint: Springer-Verlag
Country of origin: Germany
Series: Current Topics in Microbiology and Immunology, 203
Release date: December 2011
First published: 1995
Editors: Peter Sarnow
Dimensions: 235 x 155 x 10mm (L x W x T)
Format: Paperback
Pages: 183
Edition: Softcover reprint of the original 1st ed. 1995
ISBN-13: 978-3-642-79665-4
Categories: Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology
Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
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LSN: 3-642-79665-6
Barcode: 9783642796654

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