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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cap-Independent Translation (Paperback, Softcover reprint of the original 1st ed. 1995)
Loot Price: R2,762
Discovery Miles 27 620
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Cap-Independent Translation (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Current Topics in Microbiology and Immunology, 203
Expected to ship within 10 - 15 working days
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Whether or not an mRNA is translated is often thought to be a
simple function of its steady-state concentration and the ab- sence
of inhibitory proteins or RNA structures in the 5' and 3' noncoding
regions. The articles presented in this volume show an unexpected
flexibility of the eukaryotic translational appara- tus in the
mechanism of translational initiation and provide new opportunities
for regulation. Most or all mRNA molecules synthesized by RNA poly-
7 merase II in eukaryotic cells contain a 5' terminal mGpppG
dinucleotide, also known as the "cap structure. " RNAs carrying a
cap structure have been shown to be more resistant to attack by
exoribonucleases than their uncapped counterparts. Further- more,
the cap facilitates transport of the RNAs from the nucleus to the
cytoplasm. In the cytoplasm, the cap functions as a binding site
for the cap binding protein complex eIF-4, which enhances the
translation of the RNAs by the eukaryotic trans- lational
apparatus. Specifically, it has been postulated that bind- ing of
e1F-4 to the 5' terminal cap facilitates the recruitment of
ribosomal subunits onto the mRNAs via their free 5' ends (cap-
dependent translation). Accordingly, uncapped RNAs are generally
translated more poorly than capped RNAs. However, during the past 6
years both viral and cellular mRNAs have been discovered that can
be translated cap-independently.
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