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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Tissue-Protective Cytokines - Methods and Protocols (Hardcover, 2013 ed.)
Loot Price: R2,864
Discovery Miles 28 640
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Tissue-Protective Cytokines - Methods and Protocols (Hardcover, 2013 ed.)
Series: Methods in Molecular Biology, 982
Expected to ship within 10 - 15 working days
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Total price: R2,884
Discovery Miles: 28 840
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While many cytokines are known for their inflammatory action, there
is a growing interest in the tissue-protective effects of some
cytokines. The prototypic tissue-protective cytokine is EPO.
Initially described as neuro-protective, it is beneficial in animal
models of ischemic and other types of injury. Scientists had to
overcome the notion that EPO had only erythropoietic actions, was
only produced by the kidney, and that its receptor was only present
in erythroid progenitor cells. The use of in vitro and in vivo
disease models was essential to demonstrate the protective effects
of EPO. Reproducible models will be needed for the further study of
the mechanism of action of EPO and for the identification of other
tissue-protective cytokines. In Tissue-Protective Cytokines:
Methods and Protocols, expert researchers in the field detail the
key models that have been used to characterize the
tissue-protective actions of cytokines. Written in the highly
successful Methods in Molecular Biology (TM) series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, provide step-by-step
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls. Thorough and intuitive, Tissue Protective
Cytokines: Methods and Protocols aids scientists in continuing to
study tissue-protection that will be a new field of interest of
cytokine biology, both in discovering novel actions of known
cytokines and in developing new drugs.
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