The distinction between molecular immunology and immunobiology is
neces sarily arbitrary. The most rapid progress is usually made in
the blurred area between the two, when the chemist is aware of the
full significance of the biological problems, and the biologist is
alert to the contribution that a knowl edge of molecular structure
can be made to their solution. The range of scientific disciplines
able to contribute to research in immunology, which this approach
brings, is reflected in the present volume. Protein chemists worked
out the arrangement of the polypeptide chains and the amino acid
sequences of antibodies and X-ray crystallographers the three
dimensional structure, but more precise definition of the amino
acid side chain positions in the combining site is required for an
understanding of the subtleties of antibody specificity. That this
can be achieved with physical techniques such as nuclear magnetic
resonance has been shown by R. A. Dwek, and in his chapter he
summarizes these results with a minimum of technical detail. The
immune response has been shown to be dependent on complex cellular
interactions and further progress will be facilitated by
investigation of the molecular basis of these interactions. This
necessitates study of the structure and organization of the
molecules in the surfaces of lymphocytes and other cells.
General
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