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Regulation of Gene Expression by Small RNAs (Paperback)
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Regulation of Gene Expression by Small RNAs (Paperback)
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New Findings Revolutionize Concepts of Gene Function Endogenous
small RNAs have been found in various organisms, including humans,
mice, flies, worms, fungi, and bacteria. Furthermore, it's been
shown that microRNAs acting as cellular rheostats have the ability
to modulate gene expression. In higher eukaryotes, microRNAs may
regulate as much as 50 percent of gene expression. Regulation of
Gene Expression by Small RNAs brings together the pioneering work
of researchers who discuss their work involving a wide variety of
small RNA regulatory pathways in organisms ranging from bacteria to
humans. In addition to exploring the biogenesis and processing of
these regulatory RNAs, they also consider the functional importance
of these pathways in host organisms. Assisting current and future
researchers, this unique groundbreaking work - Provides a suite of
cutting-edge resources for the study of microRNA ontology and
function Includes a technology guide for those seeking to assay
microRNA expression Explores the mechanisms by which microRNAs
regulate gene expression in animal cells, including the regulation
of gene expression by RNA-mediated transcriptional gene silencing
Discusses a fast and low-cost approach for reversing genetic
influences in mammals Looks at breakthroughs in the use of
microRNA-based therapy for HIV and cancer This volume captures the
essence of the breadth and excitement surrounding the newly
discovered regulatory roles of small RNAs. The powerful new
approach in the study of gene function described in this text is
leading to some remarkable findings that have the potential to
revolutionize our understanding of genetic function and the
treatment of diseases otherwise considered intractable.
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