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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Applications of Pharmacokinetic Principles in Drug Development (Paperback, Softcover reprint of the original 1st ed. 2004)
Loot Price: R2,994
Discovery Miles 29 940
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Applications of Pharmacokinetic Principles in Drug Development (Paperback, Softcover reprint of the original 1st ed. 2004)
Expected to ship within 10 - 15 working days
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This volume is an important advancement in the application
ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to .
drug development. The series of topics presented deal with the
application of these tools to everyday decisions that a
pharmaceutical scientist encounters. The ability to integrate these
topics using PK and PO methods has optimized drug development
pathways in the clinic. New technologies in the areas of in vitro
assays that are more predictive of human absorption and metabolism
and advancement in bioanalytical assays are leading the way to
minimize drug failures in later, more expensive clinical
development programs. of Pharmacokinetics and pharmacodynamics have
become an important component understanding the drug action on the
body and is becoming increasingly important in drug labeling due to
it's potential for predicting drug behavior in populations that may
be difficult to study in adequate numbers during drug development.
The ability to correlate drug exposure to effect and model it
during the drug development value chain provides valuable insight
into optimizing the next steps to derive maximum information from
each study. These principles and modeling techniques have resulted
in an expanded and integrated view of PK and PO and have led to the
expectations that we may be able to optimally design clinical
trials and eventually lead us to identifying the optimal therapy
for the patient, while minimizing cost and speeding up drug
development. There is wide utility for the book both as a text and
as a reference.
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