"Electroporation-Based Therapies for Cancer" reviews
electroporation-based clinical studies in hospitals for various
cancer treatments, including melanomas, head and neck cancers,
chest wall breast carcinomas, and colorectal cancers, as well as
research studies in the lab using cell lines, primary cells, and
animals.
Cancer kills about one American per minute, amounting to over
500,000 deaths in the United States and millions, worldwide, each
year. There is a critical need for safe, effective, and affordable
alternative treatment modalities, especially for inoperable,
recurring, and chemo-resistant cancers, that do not respond well to
current treatment regimen. An electrical-pulse-mediated, enhanced
drug delivery technique known as electroporation is one way to
effectively treat these patients.
This technique is especially suitable for low- and middle-income
countries, where lack of infrastructure and resources leads to
cancer diagnoses at late stages. This quick, safe, effective,
economical, out-patient-based technique is a boon to these patients
for palliative and other care with enhanced quality of life. This
book features discussions by interdisciplinary authors-including
practicing oncological surgeons, medical professionals, and
academic and other researchers-of the basics and clinical medical
applications of electroporation.
Provides novel and recent clinical applications of
electrochemotherapy for various cancers, including melanomas,
sarcomas, superficial extreme melanoma, chest wall breast
carcinoma, and colorectal cancersExtensive study of a number of
cell lines, including human breast cancer, lung cancer, cervical
cancer, leukemia, and mouse breast cancer using both reversible and
irreversible electroporation techniquesIn vitro study of delivery
of various commonly prescribed/administered breast cancer chemo and
hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and
Tamoxifen
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