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Books > Medicine > Clinical & internal medicine > Rheumatology
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Antirheumatic Therapy: Actions and Outcomes (Hardcover, 2005 ed.)
Loot Price: R4,414
Discovery Miles 44 140
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Antirheumatic Therapy: Actions and Outcomes (Hardcover, 2005 ed.)
Series: Progress in Inflammation Research
Expected to ship within 10 - 15 working days
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Our goal for this book is to examine the contemporary therapy of
rheumatoid arthritis (RA) from the increasingly important
perspective of impact upon quality of life, costs and long-term
health outcomes. For too long the focus has been on short term,
symptomatic, and surrogate indicator outcomes. Yet RA is a
life-long disor der with the majority of impact on an individual
patient many years following onset. Further, even in the
short-term, researchers and rheumatologists have tended to
emphasize measurements of disease activity such as joint counts,
ESR and physi cian's opinion as to the amount of disease activity
present. It is only relatively recently that measures of structural
damage, quality of life and impact on broad domains of health have
been given increasing emphasis. Also, the significance of early
treatment of RA in order to optimise long-term outcomes has a
relatively short history [1]. We have been focussed on the disease
processes as surrogates for long term outcomes. Until the
short-term process measures are validated as surrogates of
long-term effects we should also turn our attention to outcomes of
disease and the impact of our management on those outcomes [2).
Inour view, this book is especially timely. We are at the dawn of a
revolution in the management of RA and other complex immunological
inflammatory disorders because their molecular, genetic and
environmental mechanisms are being unrav elled. Inthe process, we
are revealing a substantial number of novel and significant targets
for pharmacotherapy.
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