Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones (Hardcover, 2015 ed.)

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	July 2015
First published:	2015
Authors:	Robert Doran
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Hardcover - Cloth over boards
Pages:	202
Edition:	2015 ed.
ISBN-13:	978-3-319-20543-4
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Chemistry > Physical chemistry > Catalysis Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-319-20543-9
Barcode:	9783319205434

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