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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium (Paperback, 2012 ed.)
Loot Price: R5,905
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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium (Paperback, 2012 ed.)
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Coxiella burnetii is the etiological agent of Q fever, a zoonotic
disease found worldwide. The bacterium is a fascinating example of
intracellular parasitism that has uniquely evolved to thrive in the
most inhospitable of cellular compartments-the phagolysosome.
Understanding how C. burnetii resists the degradative functions of
this vacuole, and the host cell functions coopted for successful
parasitism, are central to understanding Q fever pathogenesis.
Recent achievements in glycomics and proteomics are guiding
development of enhanced detection schemes for the bacterium in
addition to shedding light on the host immune response to the
pathogen. Several chapters survey immune functions that control or
potentially exacerbate Coxiella infection and delve into correlates
of protective immunity elicited by vaccination. Comparative
genomics is also the foundation of chapters discussing diagnostic
antigen discovery and molecular typing of the bacterium, with
significance for development of new clinical, epidemiologic, and
forensic tools.
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