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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium (Hardcover, 2012 ed.)
Loot Price: R5,830
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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium (Hardcover, 2012 ed.)
Series: Advances in Experimental Medicine and Biology, 984
Expected to ship within 10 - 15 working days
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Over 20 years have elapsed since publication of the seminal two
volume series entitled Q Fever: The Biology of Coxiella burnetii
(edited by J. C. Williams and H. A. Thompson) and Q fever: The
Disease (edited by T. J. Marrie) that described the current state
of Coxiella burnetii research. The ensuing years have brought the
post-genomic era and accompanying technologies that have catalyzed
major advances in the field, including milestones discoveries of
genetic transformation and host cell-free growth of this former
obligate intracellular bacterium. Understanding how the bacterium
resists the degradative functions of vacuole, and the host cell
functions coopted for successful parasitism, are central to
understanding Q fever pathogenesis. Recent achievements in
glycomics and proteomics are guiding development of enhanced
detection schemes for the bacterium in addition to shedding light
on the host immune response to the pathogen. The book covers the
current state-of-the-art knowledge in the selected fields of C.
burnetii/Q fever research. Coxiella has matured from a niche
organism, investigated by a handful of laboratories worldwide, to a
model system to study macrophage parasitism, developmental biology,
host-pathogen interactions, and immune evasion/modulation.
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