We are celebrating this year the hundred years anniversary of
allergen-specific immunotherapy. In 1911 Leonard Noon published his
seminal work "Prophylactic inoculation against hay fever"
describing his attempts to achieve active immunity against "grass
pollen toxin" by administering increasing doses of grass pollen
extract before the grass pollen season to allergic patients.
Although it was unknown at that time that allergy represents an
immunological hypersensitivity disease, the treatment was effective
and many observations made by Noon remained valid until today.
Today allergen-specific immunotherapy is well established as the
only allergen-specific and disease-modifying treatment for
IgE-mediated allergies and has long-lasting effects. In fact, more
than 25% of the population suffer from IgE-mediated allergies which
therefore represent a major health burden of our society,
particularly because untreated allergy often progresses to severe
disabling forms of disease, such as asthma and sometimes kills
sensitized people through anaphylaxis."
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