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Excitement Of Discovery, The: Selected Papers Of Alexander Rich - A Tribute To Alexander Rich (Hardcover)
Loot Price: R6,031
Discovery Miles 60 310
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Excitement Of Discovery, The: Selected Papers Of Alexander Rich - A Tribute To Alexander Rich (Hardcover)
Series: Series in Structural Biology, 11
Expected to ship within 10 - 15 working days
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'This book brings back memories of the great Alex Rich, a pioneer
in molecular biology. He was friend, a mentor and a colleague who
contributed greatly to the understanding of living processes and
molecular structures.'David Baltimore1975 Nobel Laureate in
Physiology or MedicineThis book is intended for students and
general readers who are interested in the structures of biological
molecules and history of science. The center of gravity of
Alexander Rich's work is on nucleic acids and their structures and
their roles in biology, but the breadth of his work is nearly
unparalleled. Alex Rich published important early discoveries on
the structure and activity of RNA, information transfer
(translation) from RNA to protein, the structure of ribosomes with
insights into polyribosome functions, the first atomic-resolution
structure of nucleic acid base pairings, and the discovery of a
hitherto-unknown conformation of DNA. Many of Rich's articles also
have a focus on the structure of proteins in general as well as
specific proteins and some are concerned with the structure of
viruses. Some of Rich's early experimental work is based on
scattering of X-rays from fibers but X-ray diffraction from
crystals became the dominating technique of the Cold War.This is a
book full of rich history of early days of modern biology and many
fundamental discoveries. Alex Rich's main focus throughout his long
career was on nucleic acids. His first paper on nucleic acids, was
published together with JD Watson. Two years later, Rich reported
creating fibers of poly-Uracil and poly-Adenine and studied their
structures by diffraction.Alex Rich's laboratory determined the
high resolution crystal structures of the ApU and GpC fragments of
double helical RNA from Rich's group is considered a landmark in
the detailed understanding of nucleic acid structure.
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