New genomic information has revealed the crucial role that
protein–protein interactions (PPIs) play in regulating numerous
cellular functions. Aberrant forms of these interactions are common
in numerous diseases and thus PPIs have emerged as a vast class of
critical drug targets. Despite the importance of PPIs in biology,
it has been extremely challenging to convert targets into
therapeutics and targeting PPIs had long been considered a very
difficult task. However, over the past decade the field has
advanced with increasing growth in the number of successful PPI
regulators. Protein–Protein Interaction Regulators surveys the
latest advances in the structural understanding of PPIs as well as
recent developments in modulator discovery.
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