This thesis reports the latest developments in the direct amination
of various C H bonds using an H Zn exchange/electrophilic amination
strategy. McDonald and co-workers reveal this approach to be a
rapid and powerful method for accessing a variety of functionalized
amines. The material outlined in this book shows how McDonald
achieved C H zincation using strong, non-nucleophilic zinc bases
and subsequent electrophilic amination of the corresponding zinc
carbanions with copper as a catalyst and O-benzoylhydroxylamines as
the electrophilic nitrogen source. McDonald's findings are of
relevance to medicinal chemistry, drug discovery and materials
science. Her thesis is a source of inspiration for scientists
entering the field and students beginning their PhD in a related
area.
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