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MHC Protocols (Paperback, Softcover reprint of the original 1st ed. 2003)
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MHC Protocols (Paperback, Softcover reprint of the original 1st ed. 2003)
Series: Methods in Molecular Biology, 210
Expected to ship within 10 - 15 working days
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The aim of MHC Protocols is to document protocols that can be used
for the analysis of genetic variation within the human major
histocompatibility complex (MHC; HLA region). The human MHC
encompasses approximately 4 million base pairs on the short arm of
chromosome 6 at cytogenetic location 6p21. 3. The region is divided
into three subregions. The telomeric class I region contains the
genes that encode the HLA class I molecules HLA-A, -B, and -C. The
centromeric class II region contains the genes encoding the HLA
class II molecules HLA-DR, -DQ, and -DP. In between is the class
III region, originally identified because it contains genes
encoding components of the complement pathway. The entire human MHC
has recently been sequenced (1) and each subregion is now known to
contain many other genes, a number of which have immunological
functions. The study of polymorphism within the MHC is well
established, because the region contains the highly polymorphic HLA
genes. HLA polymorphism has been used extensively in solid organ
and bone marrow transplantation to match donors and recipients. As
a result, large numbers of HLA alleles have been identified, a
process that has been further driven by recent interest in HLA gene
diversity in ethnic populations. The extreme genetic variation in
HLA genes is believed to have been driven by the evolutionary
response to infectious agents, but relatively few studies have
analyzed associations between HLA genetic variation and infectious
disease, which has been difficult to demonstrate.
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