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Proteins Crossing Membranes - A Scientist's Memoir (Hardcover)
Loot Price: R5,044
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Proteins Crossing Membranes - A Scientist's Memoir (Hardcover)
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In an intriguing series of experiments carried out many years ago,
a common scientific belief, feted by no less than three Nobel
prizes, was brought into question. The observations were about
proteins-the molecules that the genetic code specifies and that are
in one way or another central to all of life's activities. The
experiments however were not about what proteins do, but how they
are moved, in particular how they are moved from where they are
made to where they act. The results of these studies conflicted
with the standard view of how this happens, and thus became
controversial. The standard view, the vesicle theory of protein
secretion, envisions proteins being carried within and out of cells
en masse in membrane-bound sacs or vesicles. The controversial
experiments demonstrated that to the contrary individual protein
molecules cross the relevant membranes as a result of their own
motion. This was thought to be impossible at the time. Proteins
Crossing Membranes is a personal narrative that tells the story of
the controversy. Among other things, the author illustrates that
scientists, like the rest of us, can rigidly hold onto their
beliefs despite evidence that they are misguided. Key Features
Reviews the data in support and critical of the vesicle theory of
protein secretion Explores the ways scientists respond to evidence
that challenges a favored theory Documents the author's personal
experiences in this conflict-laden situation
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