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Current Directions in Radiopharmaceutical Research and Development (Hardcover, 1996 ed.)
Loot Price: R4,314
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Current Directions in Radiopharmaceutical Research and Development (Hardcover, 1996 ed.)
Series: Developments in Nuclear Medicine, 30
Expected to ship within 12 - 17 working days
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Radiophannaceutical research has recently undergone a major change
in direction. In past years it has been concerned mainly with the
development of perfusion tracers, the biodistribution of which
reflect the regional blood flow to areas of major organs such as
the heart and brain. However, a major new direction of interest now
lies in the development of receptor-binding radio-tracers which can
be used to perform in-vivo characterisation of diseased tissues and
it is likely that much of the future research in this field will
follow this direction. The difficulties in developing such tracers
are considerable. The researcher must first identify a promising
target for radiopharmaceutical development. High specific activity
radioactive molecules must be designed and synthesised which will
both bind to the target receptor with high affinity, and also have
the physicochemical characteristics which will allow them to reach
the target site in sufficient quantity while at the same time
showing minimal uptake in non-target tissues. Thus the knowledge
base required for radiophannaceutical development has now expanded
beyond the limits of radiopharmaceutical chemistry to include
aspects of biochemistry, molecular biology and conventional drug
design. The portfolio of basic knowledge required to support
current radiopharmaceutical development is changing and scientists
working in this arena need to be trained in this regard. At the
same time, the very latest developments in the field need to be
communicated to the scientific community in order to stimulate the
advancement of this exciting new direction of research.
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