0
Your cart

Your cart is empty

Books > Science & Mathematics > Biology, life sciences > Cellular biology

Buy Now

Anoikis - How the Extracellular Matrix Regulates Life-or-Death Decisions (Hardcover, 1st ed. 2021) Loot Price: R3,618
Discovery Miles 36 180
Anoikis - How the Extracellular Matrix Regulates Life-or-Death Decisions (Hardcover, 1st ed. 2021): Steven M. Frisch

Anoikis - How the Extracellular Matrix Regulates Life-or-Death Decisions (Hardcover, 1st ed. 2021)

Steven M. Frisch

 (sign in to rate)
Loot Price R3,618 Discovery Miles 36 180 | Repayment Terms: R339 pm x 12*

Bookmark and Share

Expected to ship within 10 - 15 working days

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.

General

Imprint: Springer Nature Switzerland AG
Country of origin: Switzerland
Release date: July 2021
First published: 2021
Editors: Steven M. Frisch
Dimensions: 235 x 155mm (L x W)
Format: Hardcover
Pages: 202
Edition: 1st ed. 2021
ISBN-13: 978-3-03-073854-9
Categories: Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
Promotions
LSN: 3-03-073854-X
Barcode: 9783030738549

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!

Partners