Anoikis - How the Extracellular Matrix Regulates Life-or-Death Decisions (Hardcover, 1st ed. 2021)

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.

General

Imprint:	Springer Nature Switzerland AG
Country of origin:	Switzerland
Release date:	July 2021
First published:	2021
Editors:	Steven M. Frisch
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	202
Edition:	1st ed. 2021
ISBN-13:	978-3-03-073854-9
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-03-073854-X
Barcode:	9783030738549

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