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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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The Coronaviridae (Hardcover, 1995 ed.)
Loot Price: R6,253
Discovery Miles 62 530
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The Coronaviridae (Hardcover, 1995 ed.)
Series: The Viruses
Expected to ship within 10 - 15 working days
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Coronaviruses were recognized as a group of enveloped, RNA viruses
in 1968 and accepted by the International Committee on the Taxonomy
of Viruses as a separate family, the Coronaviridae, in 1975. By
1978, it had become evident that the coronavirus genomic RNA was
infectious (i. e., positive strand), and by 1983, at least the
framework of the coronavirus replication strategy had been per
ceived. Subsequently, with the application of recombinant DNA
techniques, there have been remarkable advances in our
understanding of the molecular biology of coronaviruses, and a mass
of structural data concerning coronavirus genomes, mRNAs, and pro
teins now exists. More recently, attention has been focused on the
role of essential and accessory gene products in the coronavirus
replication cyde and a molecular analysis of the structure-function
relation ships of coronavirus proteins. Nevertheless, there are
still large gaps in our knowledge, for instance, in areas such as
the genesis of coronavirus subgenomic mRNAs or the function of the
coronavirus RNA-dependent RNA polymerase. The diseases caused by
coronaviruses have been known for much longer than the agents
themselves. Possibly the first coronavirus-related disease to be
recorded was feline infectious peritonitis, as early as 1912. The
diseases associ ated with infectious bronchitis virus,
transmissible gastroenteritis virus, and murine hepatitis virus
were all well known before 1950."
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