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Platinum Coordination Complexes in Cancer Chemotherapy (Paperback, Softcover reprint of the original 1st ed. 1974)
Loot Price: R2,942
Discovery Miles 29 420
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Platinum Coordination Complexes in Cancer Chemotherapy (Paperback, Softcover reprint of the original 1st ed. 1974)
Series: Recent Results in Cancer Research, 48
Expected to ship within 10 - 15 working days
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It was a great pleasure and honour to have been invited to attend
this Seminar and to present a final impression. The association in
this field between the Chester Beatty Research Institute and Dr.
Rosenberg's School at East Lansing is something which I specially
value and many would doubtless like to know how it came about. In
the course of its work in carcinogenesis and on chemotherapy over
many years, the Chester Beatty Research Institute was frequently
drawn to the importance of many metals - as for example lead, iron,
metalloid arsenic and the metalloid quali ties of the carcinogenic
hydrocarbons. Interest started in platinum many years ago,
following the possibility, c1aimed by others, that various
complexes between the metal and mercaptopurine might possess
significant chemotherapeutic properties. Va rious attempts to
confirm such findings ended, however, in complete failure. Interest
in platinum was revived by the fresh observations of Dr. Rosenberg
and his collea gues, and here the outcome was entirely different.
Very soon it was possible to con firm the intense growth-inhibitory
properties of cis-platinum (II) diamminedi chloride and related
substances. After communicating these results to Dr. Rosenberg, it
was a pleasure to welcome hirn in London where he gave a Seminar
which greatly engaged the interest of many of the staff. Later,
several of these were to enjoy Dr. Rosenberg's hospitality at an
international conference on the subject to be held in East Lansing,
where many rapidly developing aspects were open for discussion."
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