Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty
inoculated his wife and two sons with the pus from the teat of a
cow suffering from cow pox, using his wife's knitting needle as a
vaccinating implement. It has made slow progress. Meanwhile the
science of Immunology has burgeoned so much that if all
immunologists read every page of the Journal of Immunology, let
alone the other Immunology journals, then they would have no time
left to write for it. I am pleased that some of them have found the
time to write for this volume. In spite of the rapid expansion in
immuno logical knowledge and the undreamt of complexity of the
immune system that has been unravelled, immunologists have remained
until recently erudite but therapeutically effete. Indeed anyone
purporting to treat disease by immuno logical methods has been in
danger of being labelled a quack or a crackpot. Happily things are
changing. The nine chapters of this volume detail nine quite
different approaches to manipulating the immune system for
therapeutic benefit. All are experimental and they have been
attended with greater or lesser degrees of success. In some cases
their main effect has been to elucidate the complexity of the
problem. On the other hand, there are people alive and well today
as a result of these approaches who would otherwise have perished.
Immunotherapy is here to stay and it can only get better."
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