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Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds (Paperback, Softcover reprint of the original 1st ed. 1986)
Loot Price: R2,759
Discovery Miles 27 590
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Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Chemistry of Plant Protection, 1
Expected to ship within 10 - 15 working days
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Total price: R2,769
Discovery Miles: 27 690
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Living organisms are separated from the outside world by their
membranes, which perform important roles for maintaining their
lives. Sterols are indispensable com- ponents in eukaryotic
organisms for stabilizing membranes composed of phospho- lipid
bilayers. Most prokaryotic organisms, on the other hand, do not
contain sterols in their membranes, although recent studies
indicated that the bacterium Methylo- coccus capsulatus produces
sterols 1) and many strains of Mycoplasma, bacteria without cell
walls, require sterols as an essential growth factor 2). Some
bacterial species synthesize hopanoids which are hypothesized to
function like st~rols in eu- karyotic organisms 3). Significance of
ergosterol in fungi has been recognized from the fact that the
yeast Saccharomyces cerevisiae requires ergosterol for growth, when
cultured in a strictly anaerobic condition "'. l:.lectron
microscopic studies showed that membrane structures disappeared in
the yeast grown anaerobically without a supplement of ergosterol
5.6), indicating the necessity of ergosterol for membrane
biogenesis. Further confirmation of the significant role of
ergosterol in the membranes was derived from the studies on polyene
antibiotics. In the presence of polyenes such as nystatin, filipin
and amphotericin B, fungal cells lose selective permeability of the
membranes, since polyenes interact with ergosterol, such that the
structure of the fungal membranes is disrupted 7).
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