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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Biomarkers for Endometriosis - State of the Art (Hardcover, 1st ed. 2017)
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Biomarkers for Endometriosis - State of the Art (Hardcover, 1st ed. 2017)
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This book presents an overview of the diagnostic performance of
non- or semi-invasive tests for endometriosis in peripheral blood,
endometrium, saliva, peritoneal fluid and urine. The value of
existing and emerging systems biology technologies for biomarker
development is addressed in several chapters on genetics,
microarrays, proteomics and metabolomics. Although tests with high
sensitivity and acceptable specificity have been developed,
sometimes validated in independent populations and seem promising,
more research is needed to translate these data into clinical
benefit for patients and coordinate efforts internationally to
standarize analysis, reports and operating procedures. The gold
standard to diagnose endometriosis is currently through
laparoscopic inspection with histological confirmation, a surgical
procedure with rare but significant potential risks for the
patients. A non-invasive test for endometriosis would be critical
for the early detection of endometriosis of symptomatic women with
pelvic pain and/or subfertility with normal ultrasound. This would
include nearly all cases of minimal-mild endometriosis, some cases
of moderate-severe endometriosis without a clearly visible ovarian
endometrioma and cases with pelvic adhesions and/or other pelvic
pathology, who might benefit from surgery to improve pelvic pain
and/or subfertility. Such a test would also be useful in
symptomatic women with ultrasound imaging suspicious for
endometriosis, since it may be difficult to differentiate an
ovarian endometrioma from other ovarian cysts and since the quality
of ultrasound imaging is highly variable worldwide.
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