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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Studies on Renal Disorders (Hardcover, Edition.)
Loot Price: R8,238
Discovery Miles 82 380
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Studies on Renal Disorders (Hardcover, Edition.)
Series: Oxidative Stress in Applied Basic Research and Clinical Practice
Expected to ship within 10 - 15 working days
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Conditions such as oxidative stress and hypoxia, which have a
generalized impact on the oxygen metabolism, have been implicated
in the genesis of kidney disease. This means that deepening our
understanding of the pathobiology of oxygen metabolism in such
diseases could be a fruitful path towards tangible clinical
benefits. Studies in Renal Disorder collects reviews from leading
researchers and clinical scientists working in exactly this field,
providing an overview of the latest advances. The causal role of
impaired oxygen metabolism in kidney disease has numerous clinical
implications. It affects our understanding of the therapeutic
benefits accruing from anti-hypertensive agents; the way we control
hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of
dietary approaches to the correction of obesity. The defensive
mechanisms against oxidative stress, such as the Nrf2-Keap1 system,
and hypoxia, such as the PHD-HIF system, have recently been
explored in various cells, including kidney cells. These mechanisms
include intracellular sensors for oxidative stress and hypoxia.
This means that novel approaches targeting these sensors may offer
clinical benefits in kidney disease in which oxidative stress
and/or hypoxia is a final, common pathway.
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