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Books > Medicine > Clinical & internal medicine > Haematology
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Atlas of Hematologic Neoplasms (Paperback, 2009 ed.)
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Atlas of Hematologic Neoplasms (Paperback, 2009 ed.)
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Due to its rapid development in recent years, hematopathology has
become a very complicated discipline. The current development is
mainly in two aspects: the new classification of lymphomas and
leukemias and the new techniques. The Revised European-American
Classification of Lymphoid Neoplasms (REAL classification) and the
World Health Organization (WHO) classification of hematologic
neoplasms require not only morphologic criteria but also
immunophenotyping and molecular genetics for the diagnosis of
hematologic tumors. Immunophenotyping is performed by either flow
cytometry or immunohistochemistry. There are many new monoclonal
antibodies and new equipments accumulated in recent years that make
immunophenotyping more or more accurate and helpful. There are even
more new techniques invented in recent years in the field of
molecular genetics. In cytogenetics, the conventional karyotype is
supplemented and partly replaced by the fluorescence in situ
hybridization (FISH) technique. The current development of gene
expression profiling is even more powerful in terms of subtyping
the hematologic tumors, which may help guiding the treatment and
predict the prognosis. In molecular biology, the tedious Southern
blotting technique is largely replaced by polymerase chain reaction
(PCR). The recent development in reverse-transcriptase PCR and
quantitative PCR makes these techniques even more versatile.
Because of these new developments, hematopathology has become too
complicated to handle by a general pathologist. Many hospitals have
to hire a newly trained hematopathologist to oversee peripheral
blood, bone marrow and lymph node examinations. These young
hematopathologists are geared to the new techniques, but most of
them are inexperienced in morphology. No matter how well-trained a
hematopathologist is, he or she still needs to see enough cases so
that they can recognize the morphology and use the new techniques
to substantiate the diagnosis. In other words, morphology is still
the basis for the diagnosis of lymphomas and leukemias. Therefore,
a good color atlas is the most helpful tool for these young
hematopathologists and for the surgical pathologists who may
encounter a few cases of hematologic tumors from time to time. In a
busy daily practice, it is difficult to refer to a comprehensive
hematologic textbook all the time. There are a few hematologic
color atlases on the market to show the morphology of the normal
blood cells and hematologic tumor cells. These books are helpful
but not enough, because tumor cell morphology is variable from case
to case and different kinds of tumor cells may look alike and need
to be differentiated by other parameters. The best way to learn
morphology is through the format of clinical case study. This
format is also consistent with the daily practice of
hematopathologists and with the pattern in all the specialty board
examinations. Therefore, it is a good learning tool for the
pathology residents, hematology fellows as well as medical
students. This proposed book will present 83 clinical cases with
clinical history, morphology of the original specimen and a list of
differential diagnoses. This is followed by further testing with
pictures to show the test results. At the end, a correct diagnosis
is rendered with subsequent brief discussion on how the diagnosis
is achieved. A few useful references will be cited and a table will
be provided for differential diagnosis in some cases. The major
emphasis is the provision of 500 color photos of peripheral blood
smears, bone marrow aspirates, core biopsy, lymph node biopsy and
biopsies of other solid organs that are involved with lymphomas and
leukemias. Pictures of other diagnostic parameters, such as flow
cytometric histograms, immunohistochemical stains, cytogenetic
karyotypes, fluorescence in situ hybridization and polymerase chain
reaction, will also be included. A comprehensive approach with
consideration of clinical, morphologic, immunophenotypic and
molecular genetic aspects is the best way to achieve a correct
diagnosis. After reading this book, the reader will learn to make a
diagnosis not only based on the morphology alone but also in
conjunction with other parameters.
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