This book aims to present the age-related alterations in redox
signaling networks and their diagnostic biomarkers in aging cells
using multidisciplinary approach. Establishing sensitive and
specific biomarkers of dynamic redox homeostasis is crucially
important in the development of effective antiaging and senolytic
interventions. Recent years have seen tremendous advances in the
understanding of redox signaling events which highlight the process
of aging and age-related pathologies. A major challenge in
biological aging research is developing reliable biomarkers to
determine the consequences of disrupted redox signaling networks
long before the clinical diagnosis of age-related diseases is made.
Therefore, we have chosen to concentrate on aging-induced aberrant
redox signaling networks, their biomarkers, and pathological
consequences in this book. Although oxidation is a natural
metabolic process, the imbalance in the level of oxidants and
antioxidants causes oxidative stress and eventually leads to
inflammatory conditions, diabetes, neurodegenerative diseases, and
cancer. Novel redox-sensitive biomarkers for the evaluation of
aging-induced proteinopathies such as amyloid ss and tau proteins
in Alzheimer's disease, -synuclein in Parkinson's disease, and
islet amyloid polypeptides in type 2 diabetes mellitus recently
drew the attention of researchers. Inside this textbook, readers
will find comprehensive perspectives on the association between
redox homeostasis and the aging process both at the molecular and
clinical levels. Due to the inherent relationship between impaired
metabolic activities and oxidative stress, the temporal interaction
between intermediary metabolism and disturbed redox status can lead
to greater susceptibility to aging-induced diseases and disorders,
such as cardiovascular diseases, hypertension, and diabetes. This
knowledge could be a key to continued research toward improving
medication regimens such as in cancer and cardiovascular therapies,
and procedural outcomes for patients. This book brings together
current research evidence and knowledge on redox signaling and
biomarkers in aging in chapters written by leading global experts
in this rapidly evolving field. We hope that this textbook is of
interest to a wide group of researchers, advanced students,
scientifically curious non-specialist readers and clinicians alike.
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