In all organs of the body, proteases have critical roles to play
both in normal development and functioning and in disease states.
The brain is no exception to this, with proteases having emerging
roles in synaptic plasticity, memory, neurodegenerative disorders
such as Alzheimer's, Parkinson's and prion diseases, ischemia and
traumatic brain injury, inflammatory and infectious diseases, and
tumor progression. Proteases in the Brain brings together a wide
range of topics under this central theme and highlights the large
number of proteases involved in these normal and disease
processes.
Proteases in the Brain reviews the role and regulation of
proteases in, Alzheimer's disease, brain ischemia and traumatic
brain injury, human glioma, inflammatory and infectious diseases of
the central nervous system, metabolism of the prion protein,
modulating synaptic activity, multiple sclerosis, neuronal
plasticity and memory consolidation, Parkinson's disease,
processing, conversion and inactivation of neuropeptides.
Proteases in the Brain is a timely and useful source of
information both for those well-versed in the role of proteases in
the brain, and for those who are beginning to realize the important
role of this family of enzymes in brain function and
dysfunction.
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