Diuretics: Basic, Pharmacological, and Clinical Aspects - Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26-30, 1986 (Paperback, Softcover reprint of the original 1st ed. 1987)

The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Developments in Nephrology, 18
Release date:	September 2011
First published:	1987
Editors:	V.E. Andreucci • Antonia Dal Canton
Dimensions:	235 x 155 x 33mm (L x W x T)
Format:	Paperback
Pages:	576
Edition:	Softcover reprint of the original 1st ed. 1987
ISBN-13:	978-1-4612-9227-2
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Medicine > Clinical & internal medicine > Renal medicine > General Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	1-4612-9227-1
Barcode:	9781461292272

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