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Resistance to Photodynamic Therapy in Cancer (Hardcover, 2015 ed.)
Loot Price: R3,883
Discovery Miles 38 830
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Resistance to Photodynamic Therapy in Cancer (Hardcover, 2015 ed.)
Series: Resistance to Targeted Anti-Cancer Therapeutics, 5
Expected to ship within 10 - 15 working days
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This volume provides a comprehensive review of resistance induced
by photodynamic therapy (PDT) in tumor cells. Understanding the
underlying mechanisms in this process leads to the improvement of
therapeutic modality, in combination with chemotherapy,
immunotherapy, and radiotherapy. Photodynamic therapy is a
minimally invasive therapeutic procedure that can exert a selective
or preferential cytotoxic activity toward malignant cells. The
procedure involves administration of an intrinsically non-toxic
photosensitizing agent (PS) followed by irradiation at a wavelength
corresponding to a visible absorption band of the sensitizer. In
the presence of oxygen, a series of events lead to direct tumor
cell death, damage to the microvasculature, and induction of a
local inflammatory reaction. Studies reveal that PDT can be
curative, particularly in early stage tumors and this volume
explores the potential of PDT, but also reveals strategic
approaches to overcome resistance in tumor cells.
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