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Sesquiterpene Lactones - Advances in their Chemistry and Biological Aspects (Hardcover, 1st ed. 2018)
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Sesquiterpene Lactones - Advances in their Chemistry and Biological Aspects (Hardcover, 1st ed. 2018)
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This book addresses chemical and biological aspects related to
sesquiterpene lactones (STLs). Experts in different fields have
been invited to contribute on this class of compound's chemistry,
isolation and identification, biological activities (antibacterial,
antifungal, antiviral, antitrypanosomal,
antileishmanial,antiplasmodial, antiproliferative and
antiinflammatory), synthesis, biosynthesis, derivatization and QSAR
analysis. Taxonomic and chemotaxonomic aspects related to the
Asteraceae family are also contributed. The book begins by
describing the chemical characteristics of STLs, their
classification in different skeleton types, synthesis, distribution
in nature and their most important biological properties. An
overview of the group's main representatives, based on their
importance for human health, as well as an update of the most
recently isolated STLs, follow. The authors also provide an
overview of the most common methods described in the literature for
the extraction, purification, identification and structure
elucidation of STLs, while also highlighting more recently
developed methods. Furthermore, experts in the field provide an
in-depth discussion of the most commonly employed in vitro and in
vivo antiprotozoal assays against the different stages of
parasites, as well as STLs' properties as anticancer agents in
numerous cancer cell lines and animal models. Lastly, the book
presents examples of the in vitro and in vivo activity of STLs and
their mechanism of antiprotozoal action, together with an analysis
of ultrastructural alterations, observed using TEM techniques. The
book is aimed at scientists working on natural products: both those
investigating this particular group of compounds and those who wish
to further explore its potential as new drugs for medical
conditions such as protozoal diseases and cancer.
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