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The Search for Anti-Inflammatory Drugs - Case Histories from Concept to Clinic (Paperback, Softcover reprint of the original 1st ed. 1995)
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The Search for Anti-Inflammatory Drugs - Case Histories from Concept to Clinic (Paperback, Softcover reprint of the original 1st ed. 1995)
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Perspectives on Anti-Inflammatory Drugs Inflammation is a very
complicated process of interrelated events and cas cades that does
not allow for an easily defined, focused attack for drug discovery.
It is evident from years of research and development that certain
classes of compounds (e.g., NSAIDs, steroids, and so on) have had a
meas ure of success in alleviating pain and even dampening
cellularlhormonal mechanisms involved in the process. Clear,
mechanism-related therapies (e.g., for arthritis) and targeted
drugs (e.g., for transplantation) have not been available in the
past and, in reality, research in inflammation has re lied on more
phenomenological approaches for resolving symptoms or on blatant
cytoreductive approaches in cases like organ transplantation. In
the last decade, approaches that have revealed novel cellular
pathways in which intervention is possible for lymphocyte
regulation (for example, cyclosporine and FK506) and small
molecular weight mediators (e.g., leu kotriene inhibitors) are now
either standard therapy or will be in a short time. These latter
approaches have been the result of research from the 1970s up to
the present."
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