This volume contains 29 engrossing chapters contributed by
worldwide, leading research groups in the field of chemical
biology. Topics include pre-biology; the establishment of the
genetic code; isomerization of RNA; damage of nucleobases in RNA;
the dynamic structure of nucleic acids and their analogs in DNA
replication, extra- and intra-cellular transport; molecular
crowding by the use of ionic liquids; new technologies enabling the
modification of gene expression via editing of therapeutic genes;
the use of riboswitches; the modification of mRNA cap regions; new
approaches to detect appropriately modified RNAs with EPR
spectroscopy and the use of parallel and high-throughput techniques
for the analysis of the structure and new functions of nucleic
acids. This volume discusses how chemistry can add new frontiers to
the field of nucleic acids in molecular medicine, biotechnology and
nanotechnology and is not only an invaluable source of information
to chemists, biochemists and life scientists but will also
stimulate future research.
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