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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Macrolide Antibiotics (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R4,023
Discovery Miles 40 230
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Macrolide Antibiotics (Paperback, Softcover reprint of the original 1st ed. 2002)
Series: Milestones in Drug Therapy
Expected to ship within 18 - 22 working days
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There are only very few chemical classes of antibiotics in medical
use, and these have originated over a span of more than 60 years of
research. Almost half a century ago, the first member of the
macrolides, erythromycin, was introduced as a treatment option for
bacterial infections. Erythromycin is a very complex fermentation
product obtained from the soil bacterium Saccharopolyspora ery
thraea (originally named Streptomyces erythreus). The success of
erythromycin, based on its efficacy and tolerability, stimulated
researchers throughout the world to undertake intense efforts to
understand the biology and chemistry of macrolides and to use this
experience to improve the properties of this compound class. The
second generation of macrolides, based on chemical modifications of
erythromy cin, is currently being in broad use, especially for
treatment of respiratory tract infections. We presently foresee the
introduction of a new generation of macro lides, i. e. the
ketolides, which have the potential to overcome rising resistance
problems. This monograph is intended to give the interested reader
an overview on "macrolide experience," covering important areas
from basic research to clinical use. Starting from a historic
overview, the essential basic parameters - efficacy,
pharmacokinetics, pharmacodynamics, and pharmacology - are
highlighted in order to introduce the reader to the rationale for
clinical use of macrolides. The following group of chapters cover
the complex chemistry of the macro lactone structures, giving
historic background, basic structure-activity relation ships of
various derivatization strategies, and perspectives for future
discovery of new semisynthetic macrolide antibiotics."
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