Although adenoviruses have been established for quite some time as
one of the most pliable tools to study the molecular biology of
mammalian cells, rapid progress continues to be made with this
virus system. The adenoviral genome introduced into the nucleus of
cells as a Trojan Horse, as it were, is now facili- tating
investigators to uncover details of cellular mechanisms. In this
volume twelve chapters have been collected that summarize important
current research on different mechanisms in adenovirus- infected
and -transformed cells. It has become increasingly apparent that
some of these mechanisms do not only pertain to highly specialized
strategies of the viral genome and its expres- sion or replication,
but may simultaneously shed light on events indigenous to the cell.
"Adenovirus DNA: The Viral Genome and its Expression" high- lights
the first publication of the entire annotated sequence of 35. 937
nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor
and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson
(Uppsala University) and Rich Roberts (Cold Spring Harbor) present
a survey on the structure and function of the adenovirus-2 genome
(chapter 2). A considerable amount of in- formation has been
collected on the biochemical mechanisms in- vol ved in adenov irus
DNA repl ication in human cells. Al though highly specialized in
the way of initiating DNA replication, adenov irus DNA repl ication
represents probably one of the best studied systems in work on
eukaryotic DNA replication.
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