CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful
guide for medicinal chemists and pharmaceutical scientists Drug
discovery is a lengthy and complex process that typically involves
identifying an unmet medical need, determining a biological target,
chemical library screening to identify a lead, chemical
optimization, preclinical studies and clinical trials. This process
often takes many years to complete, and relies on practitioners'
knowledge of chemistry and biology, but also--and perhaps more
importantly--on experience. Improving the success rate in discovery
and development through a thorough knowledge of drug discovery
principles and advances in technology is critical for advancement
in the field. Contemporary Accounts in Drug Discovery and
Development provides drug discovery scientists with the knowledge
they need to quickly gain mastery of the drug discovery process. A
thorough accounting is given for each drug covered within the book,
as the authors provide pharmacology, drug metabolism, biology, drug
development, and clinical studies for every case, with modern drug
discovery principles and technologies incorporated throughout.
Contemporary Accounts in Drug Discovery and Development readers
will also find Case histories used as an engaging way of learning
about the drug discovery/development process Detailed biological
rational and background information, drug design principles, SAR
development, ADMET considerations, and clinical studies The full
history of individual marketed small molecule drugs Coverage of
drug candidates that have passed Phase I clinical trials with
different modalities, such as antibody drug conjugates (ADC),
proteolysis-targeting chimera (PROTAC), and peptide drugs The
application of new technologies in drug discovery such as
DNA-encoded libraries (DEL), positron emission tomography (PET),
and physics-based computational modeling employing free energy
perturbation (FEP) Contemporary Accounts in Drug Discovery and
Development is a helpful tool for medicinal chemists, organic
chemists, pharmacologists, and other scientists in drug research
and process development. It may be considered essential reading for
graduate courses in drug discovery, medicinal chemistry, drug
synthesis, pharmaceutical science, and pharmacology. It is also a
useful resource for pharmaceutical industry labs, as well as for
libraries.
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