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Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,236
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Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells (Paperback, Softcover reprint of the original 1st ed. 2014)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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Stem cells have the ability to differentiate into all types of
cells within the body, thus have great therapeutic potential for
regenerative medicine to treat complicated disorders, like
Parkinson's disease and spinal cord injury. There will also be many
applications in drug development. However, several roadblocks, such
as safety issues and low efficiency of pluripotent stem cell (PSC)
line derivation need to be resolved before their clinical
application. This thesis focuses on these two areas, so as to find
methods to overcome the limitation. It covers deriving embryonic
stem cells (ESCs) from several different species and reports an
efficient system to generate induced pluripotent stem cells
(iPSCs), and the first iPSC mice in the world. The results in this
thesis confirm that somatic cells can be fully reprogrammed with
the four Yamanaka factors. In addition, we have found that the
Dlk1-Dio3 region can be a potential molecular marker to distinguish
the fully reprogrammed iPSCs from partially reprogrammed ones. All
of these results will help improve the safety of PSCs in the
clinical applications and increase the current low induction
efficiency of their production.
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