Vesicle Trafficking in Cancer (Hardcover, 2013 ed.)

Endocytosis and vesicular trafficking determine the landscape of the cell's exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	April 2013
First published:	2013
Editors:	Yosef Yarden • Gabi Tarcic
Dimensions:	235 x 155 x 28mm (L x W x T)
Format:	Hardcover
Pages:	393
Edition:	2013 ed.
ISBN-13:	978-1-4614-6527-0
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	1-4614-6527-3
Barcode:	9781461465270

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