Optimization of Pharmaceutical R&D Programs and Portfolios - Design and Investment Strategy (Paperback, Softcover reprint of the original 1st ed. 2015)

Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Release date:	August 2016
First published:	2015
Editors:	Zoran Antonijevic
Dimensions:	235 x 155 x 11mm (L x W x T)
Format:	Paperback
Pages:	202
Edition:	Softcover reprint of the original 1st ed. 2015
ISBN-13:	978-3-319-34312-9
Categories:	Books > Science & Mathematics > Mathematics > Probability & statistics Books > Business & Economics > Business & management > Management & management techniques > Operational research Books > Science & Mathematics > Mathematics > Optimization > General
LSN:	3-319-34312-2
Barcode:	9783319343129

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