Carbon materials pervade many aspects of modern life, from fuels and building materials to consumer goods and commodity chemicals. Reaching net-zero emissions will require replacing existing fossil-carbon-based systems with circular-carbon economies that transform wastes like CO2 into useful materials. This report evaluates market opportunities and infrastructure needs to help decision makers better understand how carbon dioxide utilization can contribute to a net-zero emissions future. Table of Contents Front Matter Summary 1 Introduction and Scope 2 Existing Infrastructure for CO2 Utilization 3 Potential Uses of CO2 in Commercial Products 4 Infrastructure Considerations for CO2 Utilization 5 Policy, Regulatory, and Societal Considerations for CO2 Utilization Systems 6 Priority Infrastructure Opportunities for CO2 Utilization Appendixes Appendix A: Committee Member Biographies Appendix B: Disclosure of Conflicts of Interest Appendix C: Information-Gathering Activities Appendix D: Acronyms and Abbreviations

The assessment of risk is complex and often controversial. It is derived from the existence of a hazard, and it is characterized by the uncertainty of possible undesirable events and their outcomes. Few outcomes are as undesirable as nuclear war and nuclear terrorism. Over the decades, much has been written about particular situations, policies, and weapons that might affect the risks of nuclear war and nuclear terrorism. The nature of the concerns and the risk analysis methods used to evaluate them have evolved considerably over time. At the request of the Department of Defense, Risk Analysis Methods for Nuclear War and Nuclear Terrorism discusses risks, explores the risk assessment literature, highlights the strengths and weaknesses of risk assessment approaches, and discusses some publicly available assumptions that underpin U.S. security strategies, all in the context of nuclear war and nuclear terrorism. Table of Contents Front Matter Summary 1 Introduction 2 The Threat of Nuclear War and Nuclear Terrorism: Classes of Scenarios 3 The History and Literature of Risk Assessment for Nuclear War and Nuclear Terrorism 4 The Use of Risk Assessment for Nuclear War and Nuclear Terrorism 5 The Structure of Risk Analysis 6 Risk Analysis Methods and Models 7 Risk Information and Risk Management Decisions 8 Conclusions and Next Steps References Appendixes Appendix A: U.S. Strategic Assumptions About Nuclear Risks Appendix B: Types of Uncertainty Appendix C: U.S. Policy-Making Structure for Nuclear War and Nuclear Terrorism Appendix D: Agendas of Committee Meetings Appendix E: Committee Member Biographies

This book identifies accumulated environmental, social and economic effects of oil and gas teasing, exploration, and production on Alaska's North Slope. Economic benefits to the region have been accompanied by effects of the roads, infrastructure and activities of oil and gas production on the terrain, plants, animals and peoples of the North Slope. While attempts have been made by the oil industry and regulatory agencies to reduce many of the adverse environmental effects, they have not been eliminated. The book makes recommendations for further environmental research related to environmental effects.

The U.S. Department of Energy's Office of Environmental Management (DOE-EM) was established by Congress in 1989 to remediate waste and environmental contamination that have resulted from nuclear weapons production and related activities. It has expended almost $200 billion on cleanup and related activities since its establishment and completed cleanup at all but 15 of the more than 100 sites. At the request of Congress, the National Academies of Sciences, Engineering, and Medicine formed a committee to provide advice on enhancing the effectiveness and efficiency of DOE-EM cleanup activities, particularly with respect to project management, contracting, and oversight practices. These recommendations were provided in two reports. The first report, Review of Effectiveness and Efficiency of Defense Environmental Cleanup Activities of DOE's Office of Environmental Management: Report 1, considered overall project management practices, project management metrics and outcomes, and contract structures and performance measures. This second report focuses on specific DOE-EM sites to assess how effective the management of the numerous projects at the sites is contributing to the wider programmatic objectives of DOE-EM.

In 2016, the National Science Foundation (NSF) established a five-year program on Understanding the Rules of Life (URoL) to identify generalizable rules that govern biological systems at micro and macro levels. At the request of NSF, the National Academies of Sciences, Engineering, and Medicine convened a series of workshops to explore the achievements of the URoL program. Presenters and participants discussed integration of multi-disciplinary, systems-level approaches, broader implications for studying highly complex systems, future scientific questions and future societal needs, and the production of generalizable rules that apply to different fields and scales. This publication summarizes the presentation and discussion of the workshop. Table of Contents Front Matter The National Science Foundation's Big Idea on Understanding the Rules of Life 1 URoL: Epigenetics 2 URoL: Microbiome 3 URoL: Building a Synthetic Cell 4 URoL: Multidisciplinary Research, Education and Training, and Broader Impacts Appendix A: Workshop Agendas Appendix B: Biographical Sketches for Workshop Planning Committee and Participants Appendix C: URoL-Funded Projects

This book assesses the 50 regional seismic networks funded by various federal, state, and private sources that operate autonomously in the United States. Most have aging equipment and suffer from declining sources of operating funds. Yet, they provide valuable scientific data as well as information about seismicity and earthquakes around their locales.
The volume describes the advent of the new National Seismic Network, operated by the U.S. Geological Survey. The National Seismic Network provides a unique opportunity to integrate the regional networks with the national network. This system will preserve the valuable work of the regional networks and enhance the capabilities of the national network.

According to surveys, the public believes the chickens it is buying are wholesome. Poultry Inspection: The Basis for a Risk-Assessment Approach looks at current inspection procedures to determine how effective the Food Safety Inspection Service is in finding dangerous levels of contaminants and disease-producing microorganisms. The book first describes the history behind the current system, noting that the amount of poultry inspected has increased dramatically while techniques and regulations have remained constant since 1968. The steps involved in an inspection are then described, followed by a discussion of alternative and innovative inspection procedures. It then provides a risk-assessment model for poultry, including submodels for each stage of processing. Risk assessment is used to protect health, establish priorities, identify problems, and set acceptable levels of risk. The model is applied both to microbiological hazards and to chemical contaminants.

Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used. At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions. Table of Contents Front Matter Summary 1 Introduction 2 Contribution of Nonhuman Primate Models to Advances in Human Health 3 Current Landscape of Use and Availability of Nonhuman Primates for NIH-Supported Biomedical Research 4 The Landscape of New Approach Methodologies 5 Future Needs and Opportunities for Nonhuman Primate Models in Biomedical Research Appendix A: Study Approach and Methods Appendix B: Data on Nonhuman Primate Use in NIH-Supported Biomedical Research Appendix C: Biographical Sketches of Committee Members and Staff Appendix D: Disclosure of Unavoidable Conflicts of Interest

The National Plant Genome Initiative was launched in 1998 as a long-term project to explore DNA structure and function in plants so that useful properties of plants can be understood, improved, and ultimately harnessed to address national needs, including agriculture, nutrition, energy and waste reduction. Experts in the community were asked to consider how to build on current accomplishments in order to address major questions in plant biology and to make recommendations for objectives for the next five-year phase of the Initiative.

The science of animal nutrition has made significant advances in the past century. In looking back at the discoveries of the 20th century, we can appreciate the tremendous impact that animal nutrition has had on our lives. From the discovery of vitamins and the sweeping shift in the use of oilseeds to replace animal products as dietary protein sources for animals during the war times of the 1900s-to our integral understanding of nutrients as regulators of gene expression today-animal nutrition has been the cornerstone for scientific advances in many areas.
At the milestone of their 70th year of service to the nation, the National Research Council's (NRC) Committee on Animal Nutrition (CAN) sought to gain a better understanding of the magnitude of recent discoveries and directions in animal nutrition for the new century we are embarking upon. With financial support from the NRC, the committee was able to organize and host a symposium that featured scientists from many backgrounds who were asked to share their ideas about the potential of animal nutrition to address current problems and future challenges.

Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Prudent Practices in the Laboratory-the book that has served for decades as the standard for chemical laboratory safety practice-now features updates and new topics. This revised edition has an expanded chapter on chemical management and delves into new areas, such as nanotechnology, laboratory security, and emergency planning. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices in the Laboratory provides guidance on planning procedures for the handling, storage, and disposal of chemicals. The book offers prudent practices designed to promote safety and includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices in the Laboratory will continue to serve as the leading source of chemical safety guidelines for people working with laboratory chemicals: research chemists, technicians, safety officers, educators, and students. Table of Contents Front Matter 1 The Culture of Laboratory Safety 2 Environmental Health and Safety Management System 3 Emergency Planning 4 Evaluating Hazards and Assessing Risks in the Laboratory 5 Management of Chemicals 6 Working with Chemicals 7 Working with Laboratory Equipment 8 Management of Waste 9 Laboratory Facilities 10 Laboratory Security 11 Safety Laws and Standards Pertinent to Laboratories Bibliography APPENDIXES Appendix A: OSHA Laboratory Standard Appendix B: Statement of Task Appendix C: Committee Member Biographies Index

The ocean has absorbed a significant portion of all human-made carbon dioxide emissions. This benefits human society by moderating the rate of climate change, but also causes unprecedented changes to ocean chemistry. Carbon dioxide taken up by the ocean decreases the pH of the water and leads to a suite of chemical changes collectively known as ocean acidification. The long term consequences of ocean acidification are not known, but are expected to result in changes to many ecosystems and the services they provide to society. Ocean Acidification: A National Strategy to Meet the Challenges of a Changing Ocean reviews the current state of knowledge, explores gaps in understanding, and identifies several key findings. Like climate change, ocean acidification is a growing global problem that will intensify with continued CO2 emissions and has the potential to change marine ecosystems and affect benefits to society. The federal government has taken positive initial steps by developing a national ocean acidification program, but more information is needed to fully understand and address the threat that ocean acidification may pose to marine ecosystems and the services they provide. In addition, a global observation network of chemical and biological sensors is needed to monitor changes in ocean conditions attributable to acidification. Table of Contents Front Matter Summary 1 Introduction 2 Effects of Ocean Acidification on the Chemistry of Seawater 3 Effects of Ocean Acidification on the Physiology ofMarine Organisms 4 Effects of Ocean Acidification on Marine Ecosystems 5 Socioeconomic Concerns 6 A National Ocean Acidification Program References Appendix A: Committee and Staff Biographies Appendix B: Acronyms Appendix C: The Effect of Ocean Acidification on Calcification in Calcifying Algae, Corals,and Carbonate-dominated Systems Appendix D: Summary of Research Recommendations from Community-based References

The ocean is central to the health of the planet and the well-being of human societies, but ongoing depletion, disruption, and pollution threaten its future. The United Nations proclaimed 2021-2030 the Decade of Ocean Science for Sustainable Development (UN Ocean Decade) in recognition of the need to sustainably manage the Ocean. U.S. participation in the Decade, guided by the U.S. National Committee, included a call for "Ocean-Shots" - ambitious, transformational research concepts that draw from multiple disciplines. More than 100 Ocean-Shots were submitted. Conducted at the request of the White House Office of Science and Technology Policy and sponsored by NASA, this report identifies exciting themes from the Ocean-Shots that will galvanize action and inspire transformative, cross-disciplinary, and multi-generational participation in the Decade. Two foundational themes undergird how to go about science: An Inclusive and Equitable Ocean calls for the involvement of a diverse and representative ocean community, and An Ocean of Data recognizes the shift toward open access for data that is collected. Four topical themes - The Ocean Revealed, The Restored and Sustainable Ocean, Ocean Solutions for Climate Resilience, and Healthy Urban Sea - represent promising areas for research investments that are consistent both with the UN Ocean Decade Outcomes and U.S. ocean priorities.

Sediments, ice, corals, and trees are just some of the natural storehouses of information that help tell the complicated history of Earth?s climate. Paleoclimate researchers use these ?proxies,? in combination with numerical models, to gain understanding of the magnitudes, rates, and drivers of past climate variability with the goal of informing understanding of current and future change in Earth?s climate system. The Paleo Perspectives on Climate Change (P2C2) program of the National Science Foundation (NSF) has advanced paleoclimate research through proxy development, data-model comparisons, and synthesis work, and has facilitated interdisciplinary collaboration that has contributed to the growth of the field. This new publication highlights discussions at a June 2021 workshop that focused on identifying potential future paleoclimate research directions to further advance understanding of past climate and better inform the public and decision makers about the expected future. Table of Contents Front Matter Overview Introduction Understanding Past Climate Forcings and Sensitivity Glacial, Ocean, and Land Processes and Feedbacks Resolving Regional Climate Change: Advancing and Synthesizing Knowledge How the Paleoclimate Community Can Better Engage on BAJEDI Issues Closing Thoughts References Appendix A: Statement of Task Appendix B: Biographical Sketches of Planning Committee Members Appendix C: Workshop Agenda

Safe Passage: Astronaut Care for Exploration Missions sets forth a vision for space medicine as it applies to deep space voyage. As space missions increase in duration from months to years and extend well beyond Eartha (TM)s orbit, so will the attendant risks of working in these extreme and isolated environmental conditions. Hazards to astronaut health range from greater radiation exposure and loss of bone and muscle density to intensified psychological stress from living with others in a confined space. Going beyond the body of biomedical research, the report examines existing space medicine clinical and behavioral research and health care data and the policies attendant to them. It describes why not enough is known today about the dangers of prolonged travel to enable humans to venture into deep space in a safe and sane manner. The report makes a number of recommendations concerning NASAa (TM)s structure for clinical and behavioral research, on the need for a comprehensive astronaut health care system and on an approach to communicating health and safety risks to astronauts, their families, and the public.

Considerable international concerns exist about global climate change and its relationship to the growing use of fossil fuels. Carbon dioxide is released by chemical reactions that are employed to extract energy from fuels, and any regulatory policy limiting the amount of CO2 that could be released from sequestered sources or from energy-generating reactions will require substantial involvement of the chemical sciences and technology R&D community. Much of the public debate has been focused on the question of whether global climate change is occurring and, if so, whether it is anthropogenic, but these questions were outside the scope of the workshop, which instead focused on the question of how to respond to a possible national policy of carbon management. Previous discussion of the latter topic has focused on technological, economic, and ecological aspects and on earth science challenges, but the fundamental science has received little attention. This workshop was designed to gather information that could inform the Chemical Sciences Roundtable in its discussions of possible roles that the chemical sciences community might play in identifying and addressing underlying chemical questions.

Over the last 30 years, water quality management in the United States has been driven by the control of point sources of pollution and the use of effluent-based water quality standards. Under this paradigm, the quality of the nation's lakes, rivers, reservoirs, groundwater, and coastal waters has generally improved as wastewater treatment plants and industrial dischargers (point sources) have responded to regulations promulgated under authority of the 1972 Clean Water Act. These regulations have required dischargers to comply with effluent-based standards for criteria pollutants, as specified in National Pollutant Discharge Elimination System (NPDES) permits issued by the states and approved by the U.S. Environmental Protection Agency (EPA). Although successful, the NPDES program has not achieved the nation's water quality goals of "fishable and swimmable" waters largely because discharges from other unregulated nonpoint sources of pollution have not been as successfully controlled. Today, pollutants such as nutrients and sediment, which are often associated with nonpoint sources and were not considered criteria pollutants in the Clean Water Act, are jeopardizing water quality, as are habitat destruction, changes in flow regimes, and introduction of exotic species. This array of challenges has shifted the focus of water quality management from effluent-based to ambient- based water quality standards. Given the most recent lists of impaired waters submitted to EPA, there are about 21,000 polluted river segments, lakes, and estuaries making up over 300,000 river and shore miles and 5 million lake acres. The number of TMDLs required for these impaired waters is greater than 40,000. Under the 1992 EPA guidance or the terms of lawsuit settlements, most states are required to meet an 8- to 13-year deadline for completion of TMDLs. Budget requirements for the program are staggering as well, with most states claiming that they do not have the personnel and financial resources necessary to assess the condition of their waters, to list waters on 303d, and to develop TMDLs. A March 2000 report of the General Accounting Office (GAO) highlighted the pervasive lack of data at the state level available to set water quality standards, to determine what waters are impaired, and to develop TMDLs. This report represents the consensus opinion of the eight-member NRC committee assembled to complete this task. The committee met three times during a three-month period and heard the testimony of over 40 interested organizations and stakeholder groups. The NRC committee feels that the data and science have progressed sufficiently over the past 35 years to support the nation's return to ambient-based water quality management. Given reasonable expectations for data availability and the inevitable limits on our conceptual understanding of complex systems, statements about the science behind water quality management must be made with acknowledgment of uncertainties. This report explains that there are creative ways to accommodate this uncertainty while moving forward in addressing the nation's water quality challenges.

Reliable collections of science-based environmental information are vital for many groups of users and for a number of purposes. For example, electric utility companies predict demand during heat waves, structural engineers design buildings to withstand hurricanes and earthquakes, water managers monitor each winter's snow pack, and farmers plant and harvest crops based on daily weather predictions. Understanding the impact of human activities on climate, water, ecosystems, and species diversity, and assessing how natural systems may respond in the future are becoming increasingly important for public policy decisions. Environmental information systems gather factual information, transform it into information products, and distribute the products to users. Typical uses of the information require long-term consistency; hence the operation of the information system requires a long-term commitment from an institution, agency, or corporation. The need to keep costs down provides a strong motivation for creating multipurpose information systems that satisfy scientific, commercial and operational requirements, rather than systems that address narrow objectives. Resolving Conflicts Arising from the Privatization of Environmental Data focuses on such shared systems.

Currently, the Departments of Defense (DOD) and Commerce (DOC) acquire and operate separate polarorbiting environmental satellite systems that collect data needed for military and civil weather forecasting. The National Performance Review (NPR) and subsequent Presidential Decision Directive (PDD), directed the DOD (Air Force) and the DOC (National Oceanic and Atmospheric Administration, NOAA) to establish a converged national weather satellite program that would meet U.S. civil and national security requirements and fulfill international obligations. NASA's Earth Observing System (EOS), and potentially other NASA programs, were included in the converged program to provide new remote sensing and spacecraft technologies that could improve the operational capabilities of the converged system. The program that followed, called the National Polar-orbiting Operational Environmental Satellite System (NPOESS), combined the follow-on to the DOD's Defense Meteorological Satellite Program and the DOC's Polar-orbiting Operational Environmental Satellite (POES) program. The tri-agency Integrated Program Office (IPO) for NPOESS was subsequently established to manage the acquisition and operations of the converged satellite. Issues in the Integration of Research and Operational Satellite Systems for Climate Research analyzes issues related to the integration of EOS and NPOESS, especially as they affect research and monitoring activities related to Earth's climate and whether it is changing.

Risk management is especially important for military forces deployed in hostile and/or chemically contaminated environments, and on-line or rapid turn-around capabilities for assessing exposures can create viable options for preventing or minimizing incapaciting exposures or latent disease or disability in the years after the deployment. With military support for the development, testing, and validation of state-of-the-art personal and area sensors, telecommunications, and data management resources, the DOD can enhance its capabilities for meeting its novel and challenging tasks and create technologies that will find widespread civilian uses. Strategies to Protect the Health of Deployed U.S. Forces assesses currently available options and technologies for productive pre-deployment environmental surveillance, exposure surveillance during deployments, and retrospective exposure surveillance post-deployment. This report also considers some opportunities for technological and operational advancements in technology for more effective exposure surveillance and effects management options for force deployments in future years.

Steel is a common component of U.S. infrastructure, but that steel can corrode when buried in soil, rock, or fill. Steel corrosion is estimated to cost the United States 3-4 percent of its gross domestic product every year, and it can lead to infrastructure failure, loss of lives, property, disruption of energy and transportation systems, and damage to the environment. Although the mechanisms of steel corrosion are well understood, limited data on subsurface corrosion and the inability to measure corrosivity directly make accurate corrosion prediction through modeling a challenge. When hazardous levels of corrosion does occur, it is difficult to determine whether the cause was related to site selection, engineering decisions, changes in subsurface conditions, or a combination of these factors. This report explores the state of knowledge and technical issues regarding the corrosion of steel used for earth applications (e.g., for ground stabilization, pipelines, and infrastructure foundations) in unconsolidated earth or rock in different geologic settings. The report summarizes mechanisms of steel corrosion, assesses the state of practice for characterizing factors in the subsurface environment that influence corrosion and corrosion rates, and assesses the efficacy and uncertainties associated with quantitative, field, and laboratory methods for predicting corrosion. The industries and experts most involved with managing buried steel should collaborate to improve multidisciplinary understanding of the processes that drive buried steel corrosion. Developing a common lexicon related to buried steel corrosion, generating new data on corrosion through collaborative long-term experiments, sharing and managing data, and developing new data analytical techniques to inform infrastructure design, construction, and management decisions are key. Industries, experts, and regulators should collaboratively develop decision support systems that guide site characterization and help manage risk. These systems and new data should undergird a common clearinghouse for data on corrosion of buried steel, which will ultimately inform better and more efficient management of buried steel infrastructure, and protect safety and the environment. Table of Contents Front Matter Summary 1 Introduction 2 Fundamentals of Steel Corrosion, Industry Applications and Approaches, and Sources of Corrosion Data 3 Subsurface Environment 4 Corrosion of Buried Steel 5 Corrosion Protection for Buried Steel 6 Standard and Evolving Subsurface Characterization 7 Standard and Evolving Monitoring Practices 8 Predictive Modeling 9 Conclusions and Recommendations References Appendix A: Biographical Sketches of Committee Members Appendix B: Meeting Agendas and Workshop Appendix C: Acronyms and Abbreviations

During the 1950s, with the Cold War looming, military planners sought to know more about how to keep fighting forces fit and capable in the harsh Alaskan environment. In 1956 and 1957, the U.S. Air Force's former Arctic Aeromedical Laboratory conducted a study of the role of the thyroid in human acclimatization to cold. To measure thyroid function under various conditions, the researchers administered a radioactive medical trace, Iodine-131, to Alaska Natives and white military personnel; based on the study results, the researchers determined that the thyroid did not play a significant role in human acclimatization to cold. When this study of thyroid function was revisited at a 1993 conference on the Cold War legacy in the Arctic, serious questions were raised about the appropriateness of the activity?whether it posed risks to the people involved and whether the research had been conducted within the bounds of accepted guidelines for research using human participants. In particular, there was concern over the relatively large proportion of Alaska Natives used as subjects and whether they understood the nature of the study. This book evaluates the research in detail, looking at both the possible health effects of Iodine-131 administration in humans and the ethics of human subjects research. This book presents conclusions and recommendations and is a significant addition to the nation's current reevaluation of human radiation experiments conducted during the Cold War. Table of Contents Front Matter Executive Summary 1 Introduction 2 Health Effect of I131 Administration in Humans 3 The Ethics of Human Subjects Research 4 Conclusions and Recommendations 5 References A. Thyroid Function in Health and Disease B. Summary of the Public Session C. Thyroid Radaition Dose Estimates for I131 D. Secretary of Defense Letter E. Informed Consent Elements of Disclosure F. Principles for the Conduct of Research in the Arctic G. Biographical Sketches of Committee Members H. Glossary

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction 2 The GenotypePhenotype Challenge 3 Case Studies on Building Functional Genomics Tools in Diverse Systems 4 Understanding the Contributions of Non-Protein-Coding DNA to Phenotype 5 Advancing Research on the Environmental Regulation of Gene Function 6 Predicting Current and Future Sources of Variation in Quantitative Traits 7 Interpreting and Validating Results from High-Throughput Screening Approaches 8 Large Databases and Consortia 9 Big-Picture Challenges in Research, Education, and Training 10 Future of Functional Genomics References Appendix A: Statement of Task Appendix B: Workshop Agenda Appendix C: Planning Committee Biographies Appendix D: Speaker Biographies Appendix E: Acronyms and Abbreviations

Hurricane- and coastal-storm-related losses have increased substantially during the past century, largely due to increases in population and development in the most susceptible coastal areas. Climate change poses additional threats to coastal communities from sea level rise and possible increases in strength of the largest hurricanes. Several large cities in the United States have extensive assets at risk to coastal storms, along with countless smaller cities and developed areas. The devastation from Superstorm Sandy has heightened the nation's awareness of these vulnerabilities. What can we do to better prepare for and respond to the increasing risks of loss? Reducing Coastal Risk on the East and Gulf Coasts reviews the coastal risk-reduction strategies and levels of protection that have been used along the United States East and Gulf Coasts to reduce the impacts of coastal flooding associated with storm surges. This report evaluates their effectiveness in terms of economic return, protection of life safety, and minimization of environmental effects. According to this report, the vast majority of the funding for coastal risk-related issues is provided only after a disaster occurs. This report calls for the development of a national vision for coastal risk management that includes a long-term view, regional solutions, and recognition of the full array of economic, social, environmental, and life-safety benefits that come from risk reduction efforts. To support this vision, Reducing Coastal Risk states that a national coastal risk assessment is needed to identify those areas with the greatest risks that are high priorities for risk reduction efforts. The report discusses the implications of expanding the extent and levels of coastal storm surge protection in terms of operation and maintenance costs and the availability of resources. Reducing Coastal Risk recommends that benefit-cost analysis, constrained by acceptable risk criteria and other important environmental and social factors, be used as a framework for evaluating national investments in coastal risk reduction. The recommendations of this report will assist engineers, planners and policy makers at national, regional, state, and local levels to move from a nation that is primarily reactive to coastal disasters to one that invests wisely in coastal risk reduction and builds resilience among coastal communities. Table of Contents Front Matter Summary 1 Introduction 2 Institutional Landscape for Coastal Risk Management 3 Performance of Coastal Risk Reduction Strategies 4 Principles for Guiding the Nation's Future Investments in Coastal Risk Reduction 5 A Vision for Coastal Risk Reduction References Appendix A: Major U.S. Coastal Storms Since 1900 Appendix B: USACE Coastal Storm Damage Reduction Projects Appendix C: Biographical Sketches of Committee Members