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This is the first of three volumes in the "Ion Channels &
Transporters in Tumor Biology" collection, which discusses the
function of ion transport proteins in cellular and systemic
homeostasis. The authors highlight the role of the so-called
transportome, which is defined by the entirety of ion transporters
and ion channels. Thereby, readers will get a better understanding
of the impact dysregulated ion transport has on the whole spectrum
of cancer types. Cancers display deficiencies in several, sometimes
interdependent members of the transportome. Clinicians will be
interested in the fact that controlled expression of ion transport
proteins dramatically impacts the life span of cancer patients, as
shown in recent studies. These observations offer a promising
outlook for biomedical scientists, as members of the transportome
could be the tumor markers of tomorrow - both for diagnostic and
therapeutic purposes. As part of a three-volume collection, this
book will fascinate members of the active research community, as
well as clinicians from the cancer field.
It has long been theorized that people living in poor areas have
more health problems than their more advantaged peers. More
recently, science has been testing this hypothesis, concentrating
on the impact of the built environment on well-being and its
contribution to health inequities. Neighbourhood Structure and
Health Promotion offers sociology-based theory and evidence-based
findings so readers may better understand the effects of place on
health choices, behaviour, and outcomes. This international volume
analyzes the complex relationships among neighbourhood conditions
and characteristics, people's perceptions of where they live, and
their everyday health lives, from eating habits and activity levels
to smoking, drinking, and drug use. Chapters introduce innovative
methods for measuring and monitoring links between place and health
in terms of risks and resources, and employing objective and
subjective data. Prospects for engaging neighbourhoods in
prevention efforts, particularly involving young people, and policy
implications for the future of health promotion and inequity
reduction are discussed as well. Included in the coverage: The
spatiality of injustice: area effects on behaviour. Qualitative and
quantitative methods for assessing neighbourhood health resources.
The potential of GIS and GPS in the health sciences. Green spaces
and health: possibilities for research and policy. School
neighbourhoods and obesity prevention in youth. Connecting gender,
social environment, and health. Neighbourhood Structure and Health
Promotion advances the study of this increasingly critical topic,
making it a valuable reference for researchers, practitioners,
policy makers and advanced students in health, health promotion,
social epidemiology, and urban planning.
This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of the
pathophysiology of cancer. The authors highlight that ion transport
proteins, channels and transporters - collectively referred to as
the transportome - are significantly involved in the development
and progression of cancer. Nearly 90% of malignant tumor diseases
originate from epithelial cells, the function of which, for the
most part, is based on the transportome. This volume focuses on
molecular principles by showing that dysregulated expression and/or
function of ion transporters have been correlated with malignancy
in the vast majority of tumor diseases. Within the story of the
various chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of a
three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
This third and final volume in the "Ion Transport in Tumor Biology"
collection presents novel diagnostic and therapeutic approaches in
cancer based on the exploitation of ion transport proteins. The
authors critically examine several transportome members,
particularly Na+, K+, Ca2+, and Cl- channels, as well as organic
solute carriers regarding their suitability as therapeutic targets.
Synergistic effects resulting from the combined use of classical
cytostatics with ion transport-inhibiting drugs are pointed out,
and the capability of bispecific antibodies to function as
anticancer drugs is discussed. As readers will also learn, the use
of ion channel inhibitors could improve the outcome of radiotherapy
because the development of radio-resistance during radiotherapeutic
treatment often correlates with increases in the expression levels
and conductance of ion channels. The translational topics of this
volume form a bridge between biochemical research and therapeutic
application. As part of a three-volume collection, this book will
fascinate members of the active research community, as well as
clinicians in the cancer field.
This third and final volume in the "Ion Transport in Tumor Biology"
collection presents novel diagnostic and therapeutic approaches in
cancer based on the exploitation of ion transport proteins. The
authors critically examine several transportome members,
particularly Na+, K+, Ca2+, and Cl- channels, as well as organic
solute carriers regarding their suitability as therapeutic targets.
Synergistic effects resulting from the combined use of classical
cytostatics with ion transport-inhibiting drugs are pointed out,
and the capability of bispecific antibodies to function as
anticancer drugs is discussed. As readers will also learn,
the use of ion channel inhibitors could improve the outcome of
radiotherapy because the development of radio-resistance during
radiotherapeutic treatment often correlates with increases in the
expression levels and conductance of ion channels. The
translational topics of this volume form a bridge between
biochemical research and therapeutic application. As part of a
three-volume collection, this book will fascinate members of the
active research community, as well as clinicians in the cancer
field.
It has long been theorized that people living in poor areas have
more health problems than their more advantaged peers. More
recently, science has been testing this hypothesis, concentrating
on the impact of the built environment on well-being and its
contribution to health inequities. Neighbourhood Structure and
Health Promotion offers sociology-based theory and evidence-based
findings so readers may better understand the effects of place on
health choices, behaviour, and outcomes. This international volume
analyzes the complex relationships among neighbourhood conditions
and characteristics, people's perceptions of where they live, and
their everyday health lives, from eating habits and activity levels
to smoking, drinking, and drug use. Chapters introduce innovative
methods for measuring and monitoring links between place and health
in terms of risks and resources, and employing objective and
subjective data. Prospects for engaging neighbourhoods in
prevention efforts, particularly involving young people, and policy
implications for the future of health promotion and inequity
reduction are discussed as well. Included in the coverage: The
spatiality of injustice: area effects on behaviour. Qualitative and
quantitative methods for assessing neighbourhood health resources.
The potential of GIS and GPS in the health sciences. Green spaces
and health: possibilities for research and policy. School
neighbourhoods and obesity prevention in youth. Connecting gender,
social environment, and health. Neighbourhood Structure and Health
Promotion advances the study of this increasingly critical topic,
making it a valuable reference for researchers, practitioners,
policy makers and advanced students in health, health promotion,
social epidemiology, and urban planning.
This book deals with a text which has been a mystery to research
concerning its temporal and spatial sphere up to now. Nevertheless
it is of great importance to understand late ancient linguistics
and their continuing influence on the Middle Ages. This comment to
Ars maior by Donat being in the tradition of Servius has been known
to be written by the Christian statesman and author Cassiodor.
Nonetheless the authorship is still not solved because assigning
the text to Cassiodor is less based on transmission, but rather on
the rash theory of a French philologist who edited the text for the
first time in the 17th century. With regard to content the tract is
about the octo partes orationis, namely the eight parts of speech
noun, pronoun, adverb, participle, conjunction, preposition and
interjection. For today's user this text has been difficult to get
hold of because just a part of the existing transmission was the
basis for the first and only edition of 1679 and its reprint of
1848. Therefore a revised edition is placed at the beginning of
this thesis which considers apart from the old version a still
existing manuscript from early Carolingian times as well as a broad
secondary transmission. The second part consists of a comment
regarding an analysis of language and content. Its aim is to answer
the questions concerning time and place of origin, its position in
literary history, its author and its continuing influence.
Consequently this specific version enriches the series of comments
written by Donat transmitted from late ancient times. Additionally
it contributes to modern linguistics regarding the research of
early stages in language theory.
This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of
the pathophysiology of cancer. The authors highlight that ion
transport proteins, channels and transporters - collectively
referred to as the transportome - are significantly involved in the
development and progression of cancer. Nearly 90% of
malignant tumor diseases originate from epithelial cells, the
function of which, for the most part, is based on the transportome.
This volume focuses on molecular principles by showing
that dysregulated expression and/or function of ion
transporters have been correlated with malignancy in the vast
majority of tumor diseases. Within the story of the various
chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of
a three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
This is the first of three volumes in the "Ion Channels &
Transporters in Tumor Biology" collection, which discusses the
function of ion transport proteins in cellular and systemic
homeostasis. The authors highlight the role of the so-called
transportome, which is defined by the entirety of ion transporters
and ion channels. Thereby, readers will get a better understanding
of the impact dysregulated ion transport has on the whole spectrum
of cancer types. Cancers display deficiencies in several, sometimes
interdependent members of the transportome. Clinicians will be
interested in the fact that controlled expression of ion transport
proteins dramatically impacts the life span of cancer patients, as
shown in recent studies. These observations offer a promising
outlook for biomedical scientists, as members of the transportome
could be the tumor markers of tomorrow - both for diagnostic and
therapeutic purposes. As part of a three-volume collection, this
book will fascinate members of the active research community, as
well as clinicians from the cancer field.
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ De Exhalationibus Seu Effluviis Johann Christian Stock, Johann
Jacob Algoewer
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Poenae Ebraeorum Capitales IV Dissertationibus Expositae:
Exhibens Earundem Obiectum Christian Stock, J. B. Haumann
This is a reproduction of a book published before 1923. This book
may have occasional imperfections such as missing or blurred pages,
poor pictures, errant marks, etc. that were either part of the
original artifact, or were introduced by the scanning process. We
believe this work is culturally important, and despite the
imperfections, have elected to bring it back into print as part of
our continuing commitment to the preservation of printed works
worldwide. We appreciate your understanding of the imperfections in
the preservation process, and hope you enjoy this valuable book.
++++ The below data was compiled from various identification fields
in the bibliographic record of this title. This data is provided as
an additional tool in helping to ensure edition identification:
++++ Poenae Ebraeorum Capitales IV Dissertationibus Expositae: De
Numero Earum Christian Stock, J. B. Haumann
Contineo Dissertatio Mathematica De Reductione Polygonorum
Irregularium Ad Polygona Regularia.
Contineo Dissertatio Mathematica De Reductione Polygonorum
Irregularium Ad Polygona Regularia.
Contineo Dissertatio Mathematica De Reductione Polygonorum
Irregularium Ad Polygona Regularia.
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