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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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From Malignant Transformation to Metastasis - Ion Transport in Tumor Biology (Hardcover, 1st ed. 2022)
Loot Price: R3,937
Discovery Miles 39 370
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From Malignant Transformation to Metastasis - Ion Transport in Tumor Biology (Hardcover, 1st ed. 2022)
Series: Reviews of Physiology, Biochemistry and Pharmacology, 182
Expected to ship within 12 - 17 working days
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This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of the
pathophysiology of cancer. The authors highlight that ion transport
proteins, channels and transporters - collectively referred to as
the transportome - are significantly involved in the development
and progression of cancer. Nearly 90% of malignant tumor diseases
originate from epithelial cells, the function of which, for the
most part, is based on the transportome. This volume focuses on
molecular principles by showing that dysregulated expression and/or
function of ion transporters have been correlated with malignancy
in the vast majority of tumor diseases. Within the story of the
various chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of a
three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
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