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This is the first of three volumes in the "Ion Channels &
Transporters in Tumor Biology" collection, which discusses the
function of ion transport proteins in cellular and systemic
homeostasis. The authors highlight the role of the so-called
transportome, which is defined by the entirety of ion transporters
and ion channels. Thereby, readers will get a better understanding
of the impact dysregulated ion transport has on the whole spectrum
of cancer types. Cancers display deficiencies in several, sometimes
interdependent members of the transportome. Clinicians will be
interested in the fact that controlled expression of ion transport
proteins dramatically impacts the life span of cancer patients, as
shown in recent studies. These observations offer a promising
outlook for biomedical scientists, as members of the transportome
could be the tumor markers of tomorrow - both for diagnostic and
therapeutic purposes. As part of a three-volume collection, this
book will fascinate members of the active research community, as
well as clinicians from the cancer field.
This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of the
pathophysiology of cancer. The authors highlight that ion transport
proteins, channels and transporters - collectively referred to as
the transportome - are significantly involved in the development
and progression of cancer. Nearly 90% of malignant tumor diseases
originate from epithelial cells, the function of which, for the
most part, is based on the transportome. This volume focuses on
molecular principles by showing that dysregulated expression and/or
function of ion transporters have been correlated with malignancy
in the vast majority of tumor diseases. Within the story of the
various chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of a
three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
This third and final volume in the "Ion Transport in Tumor Biology"
collection presents novel diagnostic and therapeutic approaches in
cancer based on the exploitation of ion transport proteins. The
authors critically examine several transportome members,
particularly Na+, K+, Ca2+, and Cl- channels, as well as organic
solute carriers regarding their suitability as therapeutic targets.
Synergistic effects resulting from the combined use of classical
cytostatics with ion transport-inhibiting drugs are pointed out,
and the capability of bispecific antibodies to function as
anticancer drugs is discussed. As readers will also learn, the use
of ion channel inhibitors could improve the outcome of radiotherapy
because the development of radio-resistance during radiotherapeutic
treatment often correlates with increases in the expression levels
and conductance of ion channels. The translational topics of this
volume form a bridge between biochemical research and therapeutic
application. As part of a three-volume collection, this book will
fascinate members of the active research community, as well as
clinicians in the cancer field.
This third and final volume in the "Ion Transport in Tumor Biology"
collection presents novel diagnostic and therapeutic approaches in
cancer based on the exploitation of ion transport proteins. The
authors critically examine several transportome members,
particularly Na+, K+, Ca2+, and Cl- channels, as well as organic
solute carriers regarding their suitability as therapeutic targets.
Synergistic effects resulting from the combined use of classical
cytostatics with ion transport-inhibiting drugs are pointed out,
and the capability of bispecific antibodies to function as
anticancer drugs is discussed. As readers will also learn,
the use of ion channel inhibitors could improve the outcome of
radiotherapy because the development of radio-resistance during
radiotherapeutic treatment often correlates with increases in the
expression levels and conductance of ion channels. The
translational topics of this volume form a bridge between
biochemical research and therapeutic application. As part of a
three-volume collection, this book will fascinate members of the
active research community, as well as clinicians in the cancer
field.
This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of
the pathophysiology of cancer. The authors highlight that ion
transport proteins, channels and transporters - collectively
referred to as the transportome - are significantly involved in the
development and progression of cancer. Nearly 90% of
malignant tumor diseases originate from epithelial cells, the
function of which, for the most part, is based on the transportome.
This volume focuses on molecular principles by showing
that dysregulated expression and/or function of ion
transporters have been correlated with malignancy in the vast
majority of tumor diseases. Within the story of the various
chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of
a three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
This is the first of three volumes in the "Ion Channels &
Transporters in Tumor Biology" collection, which discusses the
function of ion transport proteins in cellular and systemic
homeostasis. The authors highlight the role of the so-called
transportome, which is defined by the entirety of ion transporters
and ion channels. Thereby, readers will get a better understanding
of the impact dysregulated ion transport has on the whole spectrum
of cancer types. Cancers display deficiencies in several, sometimes
interdependent members of the transportome. Clinicians will be
interested in the fact that controlled expression of ion transport
proteins dramatically impacts the life span of cancer patients, as
shown in recent studies. These observations offer a promising
outlook for biomedical scientists, as members of the transportome
could be the tumor markers of tomorrow - both for diagnostic and
therapeutic purposes. As part of a three-volume collection, this
book will fascinate members of the active research community, as
well as clinicians from the cancer field.
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