This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

Embryonic stem cell research holds unique promise for developing therapies for currently incurable diseases and conditions, and for important biomedical research. However, the process through which embryonic stem cells are obtained involves the destruction of early human embryos. Katrien Devolder focuses on the tension between the popular view that an embryo should never be deliberately harmed or destroyed, and the view that embryonic stem cell research, because of its enormous promise, must go forward. She provides an in-depth ethical analysis of the major philosophical and political attempts to resolve this tension. One such attempt involves the development of a middle ground position, which accepts only types or aspects of embryonic stem cell research deemed compatible with the view that the embryo has a significant moral status. An example is the position that it can be permissible to derive stem cells from embryos left over from in vitro fertilisation but not from embryos created for research. Others have advocated a technical solution. Several techniques have been proposed for deriving embryonic stem cells, or their functional equivalents, without harming embryos. An example is the induced pluripotent stem cell technique. Through highlighting inconsistencies in the arguments for these positions, Devolder argues that the central tension in the embryonic stem cell debate remains unresolved. This conclusion has important implications for the stem cell debate, as well as for policies inspired by this debate.

This book provides a detailed introduction to the cloning of both plants and animals and discusses the important social, ethical, political, technical, and other issues related to the practice. The history of cloning experiments dates back more than a century, but advances in technology in recent decades have multiplied the potential applications of cloning-and expanded the controversies surrounding these possibilities. Cloning: A Reference Handbook provides an accessible description of the development of plant and animal cloning from the early stages of human civilization to the present day and coherently covers the science and technology involved. It reviews the essential controversies that have arisen about cloning-particularly applications involving human DNA-as researchers have advanced and extended the tools for cloning organisms. Additionally, the book discusses public opinion about cloning and the legislative and administration actions that have been taken with regard to the practice. This single-volume work provides a broad treatment of the subject, going back further in history than is the case with most texts, covering plant cloning and providing a thorough overview of the nature of animal cloning and related issues. Examples of the topics covered include the natural "cloning" processes of regeneration in plants and animals; crucial research breakthroughs on animal cloning by Robert Briggs and Thomas King, John Gurdon, Gail Martin, James Till and Earnest McCulloch, and others; and the laws that regulate which types of cloning are allowed and prohibited in the United States and in other countries. Offers an informed perspective on cloning and its potential applications in everyday life and elsewhere Includes profiles of key individuals and organizations related to the field of cloning, a Perspectives chapter, a chronology of important events in the history of cloning, and a glossary of key terms that strengthen the reader's undersatanding of the topic Supplies the necessary historical background and context for readers to understand why cloning of both plants and animals is of great importance-and why cloning technology is even more critical when it involves human beings

This volume explores the ethics of making or expanding families through adoption or technologically assisted reproduction. For many people, these methods are separate and distinct: they can choose either adoption or assisted reproduction. But for others, these options blend together. For example, in some jurisdictions, the path of assisted reproduction for same-sex couples is complicated by the need for the partner who is not genetically related to the resulting child to adopt this child if she wants to become the child's legal parent. The essays in this volume critically examine moral choices to pursue adoption, assisted reproduction, or both, and highlight the social norms that can distort decision-making. Among these norms are those that favour people having biologically related children ('bionormativity') or that privilege a traditional understanding of family as a heterosexual unit with one or more children where both parents are the genetic, biological, legal, and social parents of these children. As a whole, the book looks at how adoption and assisted reproduction are morally distinct from one another, but also emphasizes how the two are morally similar. Choosing one, the other, or both of these approaches to family-making can be complex in some respects, but ought to be simple in others, provided that one's main goal is to become a parent.

Human enhancement has become a major concern in debates about the future of contemporary societies. This interdisciplinary book is devoted to clarifying the underlying ambiguities of these debates, and to proposing novel ways of exploring what human enhancement means and understanding what practices, goals and justifications it entails.

This book explores and elaborates three theories of public reason, drawn from Rawlsian political liberalism, natural law theory, and Confucianism. Drawing together academics from these separate approaches, the volume explores how the three theories critique each other, as well as how each one brings its theoretical arsenal to bear on the urgent contemporary debate of medical assistance in dying. The volume is structured in two parts: an exploration of the three traditions, followed by an in-depth overview of the conceptual and historical background. In Part I, the three comprehensive opening chapters are supplemented by six dynamic chapters in dialogue with each other, each author responding to the other two traditions, and subsequently reflecting on the possible deficiencies of their own theories. The chapters in Part II cover a broad range of subjects, from an overview of the history of bioethics to the nature of autonomy and its status as a moral and political value. In its entirety, the volume provides a vibrant and exemplary collaborative resource to scholars interested in the role of public reason and its relevance in bioethical debate.

This book reprints Human Guinea Pigs, by Kenneth Mellanby, a seminal work in the history of medical ethics and human subject research that has been nearly unavailable for over 40 years. Detailing the use of World War II conscientious objectors who volunteered for experimentation on scabies transmission, Mellanby's book offers insight into one approach to human subject experimentation before the development of ethical oversight regulations. His work was initially published prior to the articulation of the Nuremberg Code, which makes his subsequent position as a reporter for the British Medical Journal at the Nuremberg Trials very interesting, particularly given his sometimes controversial opinions on Nazi medical experimentation. This book reprints the second edition together with commentary essays that situate Mellanby's ethical approach in historical context and relative to contemporary approaches. This volume is of particular interest to scholars of the history of human subject research.

At last, a comprehensive collection of essays that examines and advances ethical evaluations of the controversial and increasingly popular practice of embryo adoption. In the United States alone, 400,000 frozen embryos created for in vitro fertilization exist but are no longer desired for that purpose. What are we morally obliged or permitted to do about these a oesparea embryos? More of their genetic parents are considering donating these embryos to others to gestate and raise. This practice is politically volatile (figuring in debates about embryonic stem cells) and medically and morally complex. At the present time within the Roman Catholic Church there is no official teaching on embryo adoption. Catholic ethical analyses grapple with the way embryo adoption comports with respect for embryonic human life yet challenges Catholic moral critiques of assisted reproductive technologies.

This volume is the first to bring together leading philosophers and theologians to engage Catholic debates about embryo adoption in an interactive format. The editors, a philosopher bioethicist and a moral theologian, provide a helpful overview of the practice and the arguments surrounding embryo adoption. They engage neglected Catholic ethical resources and issues to advance the current debate and chart new directions in Catholic moral thinking about this intriguing practice. The volume also includes a description of embryo adoption from a physician practitioner along with reflections from a couple who successfully adopted an embryo.

Originally published in 1995, The Early Writings of Harold W. Clark and Frank Lewis Marsh is the eighth volume in the Creationism in Twentieth Century America series, reissued in 2019. The book is a collection of original writings by the prominent creationist Harold W. Clark, and the biologist, educator and young Earth creationist Frank Lewis Marsh. Although both were significant figures in the anti-evolutionist movement of the early 20th century, unlike other members of the movement, both Marsh and Clarke were trained scientists studying under eminent evolutionists of the time. Both writers struggled to reconcile new scientific understandings of geology, botany and palaeontology, supported by Darwin’s theory of evolution, with their own creationist beliefs in genesis and flood theory. Both scientists as such began to develop their own theories of evolution that remained in line with creationist beliefs. This compact and unique collection includes the writings of Marsh and Clark from this period, featuring some of their well-known works on the subject including ‘Back to Creation’ and ‘Fundamental Biology’. This volume of original sources will be of interest to academics of religion, natural history and historians of the 19th century.

This book introduces "biolaw" as an integrated and distinct field in contemporary legal studies. Corresponding to the legal dimension of bioethics, the term "biolaw" is already in use in academic and research activities to denote legal issues emerging mostly from advanced technological applications. This book is a genuine attempt to rationalize the field of biolaw after almost four decades of continuous production of relevant legislation and judgments worldwide. This experience is a robust basis for defending a) a separate legal object, covering the total of legal norms that govern the management of life as a natural phenomenon in all its possible forms, and b) an "evolutionary" approach that opens the discussion on a future conciliation of legal regulation with the Theory of Evolution on the ground of biolaw.

This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state's chemical and biological non-proliferation regime's during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

Unfit for the Future argues that the future of our species depends on our urgently finding ways to bring about radical enhancement of the moral aspects of our own human nature. We have rewritten our own moral agenda by the drastic changes we have made to the conditions of life on earth. Advances in technology enable us to exercise an influence that extends all over the world and far into the future. But our moral psychology lags behind and leaves us ill equipped to deal with the challenges we now face. We need to change human moral motivation so that we pay more heed not merely to the global community, but to the interests of future generations. It is unlikely that traditional methods such as moral education or social reform alone can bring this about swiftly enough to avert looming disaster, which would undermine the conditions for worthwhile life on earth forever. Persson and Savulescu maintain that it is likely that we need to explore the use of new technologies of biomedicine to change the bases of human moral motivation. They argue that there are in principle no philosophical or moral objections to such moral bioenhancement. Unfit for the Future? challenges us to rethink our attitudes to our own human nature, before it is too late.

This book addresses the fundamental conflict of interest that physicians face in their daily work lives between the ethics of proper medical care versus the demands of standard business practices. However, unlike other books of this sort, this one places direct responsibility for this ethical dilemma upon the shoulders of physicians themselves. Taking ethical, legal, and business perspectives into account, the book traces the historically evolving response of American physicians to ever-increasing business interests within the profession. These financial concerns now have become intrinsic not only to the practice of medicine but seemingly also to the character of a growing segment of its practitioners. The book offers a plea for a change to a more socialized healthcare system as used in other advanced nations.

Ethical Futures and Global Science Fiction explores the ethical concerns and dimensions of representations of the future of global science fiction, focusing on the issues that dominate utopian, dystopian and science fiction literature. The essays examine recent visions of the future in science fiction and re-examine earlier texts through contemporary lenses. Across fourteen chapters, the collection considers authors from Algeria, Australia, Canada, China, Egypt, France, Germany, Haiti, India, Jamaica, Macedonia, Mexico, Russia, South Africa, the UK and USA. The volume delves into a range of ethical questions of immediate contemporary relevance, including environmental ethics, postcolonial ethics, social justice, animal ethics and the ethics of alterity.

Books do not come about by accident. This is especially the case when a volume grows out of a conference for which the participants wrote the original contributions in different languages. This volume descends from a conference held at the Zentrumjiir interdiszipliniire Forschung, University of Bielefeld, Germany, October 4 through 6, 1990, under the title "Technische Eingriffe in die menschliche Reproduktion: Per- spektiven eines moralischen Konsenses". Many with great generosity helped to ensure that the conference was a success and that the papers presented grew into a book. We want in particular to acknowledge our deep gratitude to the Zentrumjiir interdiszipliniire Forschung for spon- soring this important conference, and to its director, Peter Weingart, for his important guidance and support. Our thanks are also due to all of the staff ofthe Zentrum. It is they who made the conference successful. We are also grateful to Prof. Hilmar Stolte, head of the Institut jiir System- und Technologieanalysen in Bad Oeynhausen, Germany, for making available additional financial support for the conference. Our thanks are also owed to the participants who inspired us to transform a collection of papers into a completed volume. The general trans- formation of the original papers required translation. Here we must acknowledge the labors of Sarah L. Kirkby, who rendered many parts of the volume into English. Finally, we want to recognize the invaluable support given by the ecumenical teamwork of Kurt W.

Transplantation is a medically successful and cost-effective way to treat people whose organs have failed-but not enough organs are available to meet demand. Ethics and the Acquisition of Organs is concerned with the major ethical problems raised by policies for acquiring organs. The main topics are the rights of the dead, the role of the family, opt in and opt out systems, the conscription of organs, living organ donation from adults and children, directed donation and priority for donors, and the sale of organs. In this ground-breaking work, T. M. Wilkinson uses concepts from moral and political theory such as autonomy, rights, posthumous interests, justice, and well-being, in a context informed by the clinical, legal, and policy aspects of transplantation. The result is a rigorous philosophical exploration of real problems and options. He argues that the ethics of acquiring organs for transplantation is not only of great intellectual interest, but also of practical importance. As such, this book will be of profit not only to students and academics who work in applied ethics and bioethics, but also to the lawyers, policy-makers, clinicians, and lobby groups interested in transplantation.

Long before it cured disease, medicine aimed to relieve suffering- but despite that precedence, the relief of suffering often takes a back seat in today's biomedical research and treatment. Modern bioethics, too, has been slow to come to terms with suffering. Attention to ethical quandaries has sometimes displaced attention to the experience of patients. This book seeks to place suffering at the center of bioethical thinking once again. Among the questions its contributors explore are: What is the meaning of suffering? How does it relate to pain? If there can be pain without suffering, can there be suffering without pain? Does suffering require advanced cognitive abilities? Can animals suffer? Many believe that we have strong obligations to relieve or minimize suffering; what are the limits of these obligations? Does the relief of suffering justify the termination of a patient's life, as proponents of euthanasia maintain? What is the bearing of suffering on the cherished bioethical principle of autonomy? Can suffering impair a patient's ability to make reasoned choices? To what extent must the encounter with suffering be an important component of medical education? Do religious traditions ever move from efforts to explain and relieve suffering to positions that justify and promote it? The aim of this book is to undertake a new foray into this "foreign territory" of suffering. With a foreword by the distinguished bioethicist Daniel Callahan, its twenty-two chapters, authored by leading scholars in science and bioethics, are organized so as to examine suffering in its biological, psychological, clinical, religious, and ethical dimensions.

This volume presents the first collection of essays dedicated to the science fiction of microbiologist Joan Slonczewski. Posthuman Biopolitics consolidates the scholarly literature on Slonczewski's fiction and demonstrates fruitful lines of engagement for the critical, cultural, and theoretical treatment of her characters, plots, and storyworlds. Her novels treat feminism in relation to scientific practice, resistance to domination, pacifism versus militarism, the extension of human rights to nonhuman and posthuman actors, biopolitics and posthuman ethics, and symbiosis and communication across planetary scales. Posthuman Biopolitics explores the breadth and depth of Joan Slonczewski's vision, uncovering the reflective ethical practice that informs her science fiction.

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

This volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section. It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.

This open access book provides the first critical history of the controversy over whether to cull wild badgers to control the spread of bovine tuberculosis (bTB) in British cattle. This question has plagued several professional generations of politicians, policymakers, experts and campaigners since the early 1970s. Questions of what is known, who knows, who cares, who to trust and what to do about this complex problem have been the source of scientific, policy, and increasingly vociferous public debate ever since. This book integrates contemporary history, science and technology studies, human-animal relations, and policy research to conduct a cross-cutting analysis. It explores the worldviews of those involved with animal health, disease ecology and badger protection between the 1970s and 1990s, before reintegrating them to investigate the recent public polarisation of the controversy. Finally it asks how we might move beyond the current impasse.

This Dictionary presents a broad range of topics relevant in present-day global bioethics. With more than 500 entries, this dictionary covers organizations working in the field of global bioethics, international documents concerning bioethics, personalities that have played a role in the development of global bioethics, as well as specific topics in the field.The book is not only useful for students and professionals in global health activities, but can also serve as a basic tool that explains relevant ethical notions and terms. The dictionary furthers the ideals of cosmopolitanism: solidarity, equality, respect for difference and concern with what human beings- and specifically patients - have in common, regardless of their backgrounds, hometowns, religions, gender, etc. Global problems such as pandemic diseases, disasters, lack of care and medication, homelessness and displacement call for global responses.This book demonstrates that a moral vision of global health is necessary and it helps to quickly understand the basic ideas of global bioethics.

This book offers new direction in disability studies, by integrating the medical and social model of disability. The first aim is to provide an integral approach to thinking about impairment and disability through the integrative lens of being vulnerable. The second aim is to transcend the normative trap which impairment and disability debate finds itself locked in. Disability debate is trapped in a normative struggle to escape oppressive norms. Either, by legitimizing the desire to be free from impairment, where a legitimization identity is promoted through the medical model. Or, by resisting discriminative social norms, where the desire is to be free from oppressive social barriers that exist on top of having impairment. Identifying with one's vulnerability, or embodied uncertainty, allows for the possibility of forging meaning and building new identity. It allows freedom to express embodied difference, rather than to transform or defend it.

Cryonics-also known as cryopreservation or cryosuspension-is the preservation of legally dead individuals at ultra-low temperatures. Those who undergo this procedure hope that future technology will not only succeed in reviving them, but also cure them of the condition that led to their demise. In this sense, some hope that cryopreservation will allow people to continue living indefinitely. This book discusses the moral concerns of cryonics, both as a medical procedure and as an intermediate step toward life extension. In particular, Minerva analyses the moral issues surrounding cryonics-related techniques (including the hypothetical cryosuspension of fetuses as an alternative to abortion) by focusing on how they might impact the individuals who undergo cryosuspension, as well as society at large.

This work challenges the current reliance on "The Three R's" or Replacement, Reduction and Refinement which direct most animal research in the behavioral sciences. The author argues that these principles that were developed in the 1950's to guide the use of animals in research studies are outdated. He suggests that the notions of refinement and reduction are often ill-defined and can be useful only in cases where replacement is impossible.