Advanced Separations by Specialized Sorbents opens a new window into sorbent materials, presenting fundamental principles for their syntheses and adsorption properties. The book presents advanced techniques used to create specialized sorbents with a wide range of functions that can be used to enhance the separation and/or purification of useful bioactive compounds, heavy metals, dyes, and other substances. It discusses the most recent developments in the field of separation processes, covering specialized sorbents such as monolith cryogels, composite hydrogels, metal-impregnated ion exchangers, and molecularly imprinted polymers. The book provides a comprehensive discussion of the selectivity in separation processes by composite materials based on synthetic polymers/biopolymers and inorganic particles. It is a comprehensive resource for academic and research scientists as well as students interested in the preparation, characterization, and application of specialized sorbents.

Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market-the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.

Ion-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. The possibilities for this technology continue to grow as novel ion-pair reagents and strategies are introduced at an accelerated level. Compensating for a dearth in the literature, Ion-Pair Chromatography and Related Techniques details the basics and the evolution of this established and easily tunable technique and explains its influence on similar methods.

Theoretical modeling to application

Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in the life science, medicine, pharmacology, forensic, food, and environmental sectors. It examines the upgrade of column technology and instrumentation to improve data quality and to increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques.

Future endeavors

IPC has the potential to have lasting impact in the field of chromatography. Distilling the knowledge gained from preeminent research, this volume is a critical resource that is destined to stimulate future endeavors by separation scientists working in the area of high performance liquid chromatography.

For more than four decades, scientists and researchers have relied upon the Advances in Chromatography Series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Covering the state of the art in separation science, this volume continues to present timely, cutting-edge reviews on chromatography in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. Compiled by leading researchers from around the world, new chapters cover topics related to countercurrent chromatography and large-scale genotyping as well as cyclic voltammetry detection, a powerful tool for determining the electrochemical characteristics of organic compounds.

Focusing on what has been one of the driving forces behind the development of lab-on-a-chip devices, Separation Methods in Microanalytical Systems explores the implementation, realization, and operation of separation techniques and related complex workflows on microfabricated devices. The book details the design, manufacture, and integration of diverse components needed to perform an entire analytical procedure on a single miniaturized device. The content applies to a diversity of disciplines including chemical analysis, biomedical diagnostics, environmental monitoring, and drug discovery.

Separation Methods in Microanalytical Systems lays its theoretical background in a way that scientists from varied disciplines can approach. The book describes factors that influence the performance of separation, such as microfluidic handling, sample pre-treatment, and detection. It also conveys fabrication and material issues, design challenges, and practical considerations. Several chapters describe specific separation techniques that are central to micro-Total Analysis Systems (-TAS) as well as novel methods and emerging trends in microchip-based separations. The book also provides an applications overview that supplies a wealth of examples that help scientists put their ideas in perspective with already existing solutions.

This multi-authored volume offers different styles, approaches, and opinions for a given problem, reflecting the various angles researchers take to handle the same issues. A one-stop guide for understanding, designing, and working with separation techniques in microanalytical devices, Separation Methods in Microanalytical Systems is a valuable reference for scientists andengineers already preparing to meet the anticipated demand for function-specific chemical separation systems.

For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Volume 44 of this authoritative series once again compiles the work of expert contributors in order to present timely and cutting-edge reviews on a variety of related topics.
Each author's clear presentation of topics and vivid illustrations make the material in Advances in Chromatography: Volume 44 accessible and engaging to biochemists and analytical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

This book investigates current trends in chemometrics, proteomics, column technology, and element-selective detection for pharmaceutical, medical, industrial, and environmental applications. It offers recent strategies to evaluate and assess materials in air, water, soil, and landfill samples, to determine the amount of hydrocarbons in the atmosphere and calculate their atmospheric lifetimes, to utilize microfluidic devices for small-volume biological analyses, and to examine the role of proteins in cellular signaling, structures, and pathways. With contributions from leading authorities, this text is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists, chromatographers, biochemists, biotechnologists, and upper-level undergraduate and graduate students in these disciplines.

This is the 41st volume in the series Advances in Chromatography. The papers in this volume: take advantage of the properties of electroosmotic flow to explore capillary electrochromatography as an alternative to HPLC for nonvolatile analytes; analyze advances in biomembrane chromatography using reverse-phase HPLC for protein purification and biophysical studies of peptides and proteins at lipid-like surfaces; focus on trace metal determination and speciation performed by liquid chromatography methods; and more.

Chromatography has been developed as a powerful and rapid technique for the separation of compounds with highly similar molecular characteristics, even from complicated matrices. Due to their excellent separation characteristics and versatility, chromatographic methods have found growing acceptance and application in environmental protection for residue analysis in air, ground and surface waters, sewage, sludge, and soil matrices. This is a compilation and concise evaluation of results in this rapidly developing domain of chromatography, with a brief enumeration of the methods applied and a critical discussion of the results. The book gives gas-liquid, thin-layer, high-performance liquid, supercritical fluid chromatographic and capillary electrophoretic analysis of pollutants belonging to different compound classes. The book should be of interest to analytical chemists in legalisation and research, and analytical control specialists, as well as researchers and students.

Micellar Liquid Chromatography reviews the use of surfactant solutions at or above the critical micelle concentration as mobile phases in liquid chromatography. It employs a computer-assisted optimization methodology and integrates micellar liquid chromatography (MLC) with other chromatographic and electrophoretic techniques using surfactants. It also includes the MICHROM software package on CD-ROM to facilitate the application of equations and optimize efficiency of MLC systems.

This work introduces scientists of all disciplines to the chromatographic process and how it functions. The basic principles of chromatographic separation and specific chromatographic procedures, including gas, liquid and thin-layer chromatography, are covered. For each separation method the book details its characteristics, the instrumentation required, the procedures necessary for effective use, areas of application and examples of its use.;This work is intended for analytical chemists, laboratory technicians, and upper-level undergraduate and graduate students in analytical chemistry or separation science courses.

"Volume 35 examines timely subjects such as performance requirements, detection modes, and ancillary techniques for optical detectors in capillary electrophoresis; and more."

"Handbook of Chromatography: Analysis of Lipids" provides a valuable review of state-of-the-art applications of chromatographic techniques (TLC, GC, HPLC) and other analytical techniques. Much of this volume is devoted to applications of HPLC (including supercritical fluid chromatography) in the analysis of lipids such as fatty acids, oxygenated fatty acids, enantiomeric acyl- and alkylglycerols, and lipoproteins. The handbook also provides extensive coverage of applications of combinations of various chromatographic techniques used in the analysis of ozonides, anacardic acids, glycerophospholipids, products of lipolysis, artifacts and contaminants in edible fats, acylated proteins, non-caloric lipids, lipophilic vitamins, acyl-Coenzyme A thioesters, dolichols, mycolic acids, technical fats and fat products, and liposomes.
"Handbook of Chromatography: Analysis of Lipids" will be a useful reference for oil chemists, biochemists, fat science technologists, and other scientists involved in lipid research.

Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development engineers, process development managers, bioprocess technologists, analytical and clinical chemists and biochemists, pharmacists, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.

The Advances in Chromatography series provides the most up-to-date information on a wide range of developments in chromatographic methods and applications. For more than five decades, scientists and researchers have relied upon this series to cover the state of the art in separation science. With contributions from among the leading researchers around the world, this respected series continues to present timely, cutting-edge reviews in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. With contributions from leading authorities, this is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists; chromatographers; biochemists and biotechnologists; scientists in Academia, government, hospitals and industry in both research and quality control. This is Volume 32 originally published in 1991.

The Advances in Chromatography series provides the most up-to-date information on a wide range of developments in chromatographic methods and applications. For more than five decades, scientists and researchers have relied upon this series to cover the state of the art in separation science. With contributions from among the leading researchers around the world, this respected series continues to present timely, cutting-edge reviews in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. With contributions from leading authorities, this is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists; chromatographers; biochemists and biotechnologists; scientists in Academia, government, hospitals and industry in both research and quality control. This is Volume 30 and looks at Selectivity and Retention, originally published in 1989.

The Advances in Chromatography series provides the most up-to-date information on a wide range of developments in chromatographic methods and applications. For more than five decades, scientists and researchers have relied upon this series to cover the state of the art in separation science. With contributions from among the leading researchers around the world, this respected series continues to present timely, cutting-edge reviews in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. With contributions from leading authorities, this is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists; chromatographers; biochemists and biotechnologists; scientists in Academia, government, hospitals and industry in both research and quality control. This is Volume 27 originally published in 1987.

Thoroughly revised and expanded, the third edition of the Encyclopedia of Chromatography is an authoritative source of information for researchers in chemistry, biology, physics, engineering, and materials science. This quick reference and guide to specific chromatographic techniques and theory provides a basic introduction to the science and technology of the method, offering key references dealing with the methodology for analysis of specific chemicals and applications in industry. With a focus on emerging technologies and uses, the text contains tables and figures that cogently illustrate and clarify technical points in the articles. The Third Edition provides a valuable, reader-friendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances, as well as practitioners across the entire spectrum of science.

What s New in the Third Edition:

Bioanalysis: Silica- and Polymer-Based Monolithic Columns Bioluminescence: Detection in TLC Chemical Warfare Agent Degradation Products: HPLC/MS Analysis Chemical Warfare Agents: TLC Analysis Cyclodextrins in GC Cyclodextrins in HPLC Detection in Ion Chromatography Drug Development: LC/MS Flash Chromatography Food Analysis: Ion Chromatography Inorganic and Organic Cations: Ion Chromatographic Determination Inverse GC Multidimensional Separations Spiral Column Assembly for HSCCC Thin Layer Radiochromatography Topological Indices: TLC UV-Visible Detection Including Multiple Wavelengths

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This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for both researchers, students, and librarians, including:

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For more information, visit Taylor and Francis Online. Or contact us to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367 / (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062 / (E-mail) [email protected]

A source of information on chromatographic techniques and methodologies for the solution of analytical and preparative problems applicable across many disciplines. Entries are arranged alphabetically from Absorbance Detection in Capillary Electrophoresis to Zone Dispersion.