Studies on Diabetes examines how increased oxidative and nitrosative stress - one of the leading causes of diabetes complications - pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease. Their contributions represent a wealth of knowledge on and research into how diabetes triggers metabolic abnormalities that lead to hyperactivation of cellular and mitochondrial pathways that ultimately result in oxidative and nitrosative stress that left un-neutralized, results in tissue damage. Each chapter provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease. Potential treatments for diabetes complications from animal models to the patient will also be discussed. This is essential reading for researchers and clinicians in endocrinology, diabetes, vascular disease and oxidative stress.

A hot topic with increasing importance

Integrating contemporary scientific developments with practical management

Written by leaders in the field of pediatric diabetes with extensive practical knowledge

In 1981, David Jenkins, Thomas Wolever, and colleagues introduced the concept of the glycemic index (GI) to differentiate carbohydrates based on the rate of blood glucose rise following their consumption. Although GI was first used in diet therapy for diabetes, research evidence has accumulated since then to thousands of publications from all over the world with applications for prevention and/or management of many diseases, as well as effects on physiological states and exercise. The Glycemic Index: Applications in Practice has gathered together, in an unbiased and critical way, all the evidence and research on GI, including diabetes, cardiovascular disease, cancer, obesity, polycystic ovary syndrome, pregnancy outcomes, sports performance, eye health, and cognitive functioning. It provides a detailed explanation on how to correctly measure a food's GI, how the GI of food products can be altered, as well as the use and misuse of GI labelling around the globe. The contributors are either pioneers or experts in the area of GI from all around the globe, including Australia, Canada, Europe, and the United States. The book is a valuable source of information for healthcare professionals of various disciplines, nutritionists, dietitians, food scientists, medical doctors, sports scientists, psychologists, public health (nutrition) policy makers, and students in these fields, as well as an important addition to university libraries.

Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed.Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs - many based on incretin action - have been added to the therapeutic armoury.Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice.Incretin Biology - A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject.

Examining the layers of meaning encoded in software and the rhetoric surrounding it, this book offers a much-needed perspective on the intersections between software, morality, and politics. In software development culture, evangelism typically denotes a rhetorical practice that aims to convert software developers, as well as non-technical lay users, from one platform to another (e.g., from the operating system Microsoft Windows to Linux). This book argues that software evangelism, like its religious counterpart, must also be understood as constructing moral and political values that extend well beyond the boundaries of the development culture. Unlike previous studies that locate such values in the effects of code in-use or in certain types of code like free and open source (FOSS) software, Maher argues that all code is meaningful beyond its technical, executable functions. To facilitate this analysis, this study builds a theory of evangelism and illustrates this theory at work in the proprietary software industry and FOSS communities. As an example of political liberalism at work at the level of code, these evangelical rhetorics of software construct competing conceptions of what is good that fall within a shared belief in what is just. Maher illustrates how these beliefs in goodness and justice do not always execute in replicable ways, as the different ways of decoding software evangelisms in the contexts of Brazil and China reveal. Demonstrating how software evangelisms exert a transformative force on the world, one comparable in significance to code itself, this book highlights the importance of rhetoric in even the most seemingly a-rhetorical of technical endeavors and foregrounds the crucial need for rhetorical literacy in the digital age.

The low-carb lifestyle continues to be a popular choice among those trying to lose weight through the ketodiet, resolve insulin resistance, and combat pre-diabetes and Diabetes. Those in the gluten-free and Paleo/Primal diet communities are also searching for recipes with that, help the gut, work with their lifestyle and benefit their health. Foods that are high in fat and low in carbs are, in some cases, just what the doctor ordered. Bestselling low-carb author and advocate, Dana Carpender, strips away the carbohydrates (grains and starches) and reveals 200 of her best ultra-low carb recipes for those who are looking to take their low-carb lifestyle to the next level. These recipes have been recipes updated to be Paleo/Primal-friendly, featuring no artificial sweeteners, gluten, or other processed ingredients. The official cookbook of HEAL Diabetes and Medical Weight Loss Centers, founded by Dr. Eric Westman, this book has 200 recipes to jumpstart your nutrition and get you on the path to a healthier, happier you.

This comprehensive text is unique in its compilation of experiences in addressing the global diabetes epidemic and description of diverse worldwide prevention initiatives. Background chapters describe the diagnosis and definition of diabetes, the epidemiology, pathophysiology of prediabetes as well as clinical trial evidence for diabetes prevention and treatment. Furthermore, the critical role of government in formulating a global health agenda, policy perspectives for European initiatives, the importance of nutritional policies for diabetes prevention as well as the development of the necessary capacity and infrastructure for diabetes prevention are described. Given the prevalence of diabetes in South Asians and migrants, one chapter focuses on risk factors and prevention of diabetes in these communities. Other chapters detail local and regional approaches covering a truly global span: United States, Latin America, Europe, India, Turkey, (Siberia) Russia, the Middle East and North Africa, South Africa, Israel, East Asia and Australia.Authored by academic experts in endocrinology and diabetes and global leaders in epidemiology and public health, this landmark text is an authoritative reference for a diverse audience including government, public health and policy experts and researchers, academicians, healthcare professionals, endocrinologists and clinicians interested in prediabetes and diabetes prevention, graduate students and faculty in public and global health graduate programs, epidemiologists, nutritionists, sociologists and those in translational medicine. Readers will broaden their awareness of the prevailing and burgeoning diabetes epidemic and the remarkably creative worldwide prevention initiatives undertaken to address the seemingly insurmountable inherent challenges posed by this global health care crisis. The text is an attestation to the wonderful potential for enormous human collaboration and achievement when communal organizations, governments at local, regional and national levels, researchers, the medical and public health communities, and nutrition experts join with global citizenry in confronting one of the most significant healthcare challenges witnessed in this century.

Few diabetes books focus specifically on the day-to-day issues facing people who use insulin. Diabetes educator Gary Scheiner provides the tools to 'think like a pancreas' -- to successfully master the art and science of matching insulin to the body's ever-changing needs. Comprehensive, free of medical jargon, and packed with useful information not readily available elsewhere, such as: day-to-day blood glucose control and monitoring designing an insulin program to best match your lifestyleup-to date medication and technologynew insulin formulations and combinationsand moreWith detailed information on new medications and technologies -- both apps and devices -- surrounding insulin, as well as new injection devices, and dietary recommendations, Think Like a Pancreas is the insulin users go-to guide.

This practical guide for teens with diabetes talks about issues specific to teens ages 16 to 19. It includes multiple no-nonsense tips that demonstrate how life with diabetes can be lived to the fullest. By identifying strategies to help manage high and low blood glucose and giving you ideas on how to get through the everyday drudge without giving up on your diabetes management, author Katherine Moran provides an essential source that is filled with informative and engaging photographs and illustrations, historical tidbits, and an index. Chapters cover using a meal plan and counting carbohydrates; understanding insulin therapy and oral medications; using physical activity to control glucose levels; dealing with other illnesses and preventing complications; being a safe and responsible driver; maintaining good health when traveling; overcoming peer pressure; and creating effective coping strategies for managing and living with diabetes. With the help of this book, teens will learn more about just what diabetes is, the treatment, how to handle the negative feelings it spans, and how to stay healthy and maintain an active life. Written in teen speak, Diabetes: The Ultimate Teen Guide, is a practical, hands-on guide that addresses the social and health issues specific to diabetic teens ages 16 to 19. Intended to empower teens to take control over the diabetes through effective disease management, they learn how to stay healthy and live life to the fullest-even with diabetes-through this no-nonsense guidance. Chapters cover using a meal plan and counting carbohydrates; understanding insulin therapy and oral medications; using physical activity to control glucose levels; dealing with other illnesses and preventing complications; being a safe and responsible driver; maintaining good health when traveling; overcoming peer pressure; and creating effective coping strategies for managing and living with diabetes. Filled with informative and engaging photographs and illustrations, historical tidbits, and a

This book covers the most important clinical and bench science aspects of metabolic syndrome. It will be of value to all of those seeking a comprehensive update on the metabolic syndrome. Furthermore, it will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.

Over the past two decades, type 2 diabetes has emerged as a leading threat to global health, and the considerable overlap in obesity and diabetes trends are likely no coincidence. While the underpinnings for both etiologies are linked to lifestyles, particularly dietary and physical activity patterns, determining optimal approaches for preventing and managing type 2 diabetes using dietary composition remains a challenge. Nutrition and Type 2 Diabetes: Etiology and Prevention rigorously examines various perspectives on diet and type 2 diabetes. The book presents a comprehensive description and evaluation of the central research to date, primarily in humans, on the macronutrients and their subclasses, micronutrients, foods, beverages, and overall dietary patterns with respect to the risk of type 2 diabetes. It addresses the mediating/mechanistic role of obesity and body composition throughout the text where appropriate. The chapter authors, all leading researchers in the field, discuss fundamental nutritional principles applied to the pathophysiology of type 2 diabetes as well as applied behavioral studies on nutrition and diabetes for each subject area. The depth and breadth of this book includes aspects of the "food synergy" model for understanding the complicated pathways between nutrition, dietary habits, and risk for type 2 diabetes. It also examines the effects of artificially sweetened beverages and coffee. This reference provides a review of the science on the potential impact of many components of dietary behavior and nutritional properties on etiology and risk for this disease, knowledge that is essential for formulating informed approaches to public health progress in this area.

International experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity. The authors discuss in detail their diagnosis, clinical manifestations, complications, and best practices for diagnosis and treatment. They also review the history and epidemiology of these conditions, explain their genetics and pathophysiology, and illuminate their known mechanisms and interactions. State-of-the-art survey-chapters critique current approaches (lifestyle and pharmacological) to the treatment of these conditions.

This book provides a comprehensive guide for all healthcare professionals managing diabetic foot problems including general practitioners, nurses, podiatrists, orthopaedic surgeons, vascular surgeons and endocrinologists. It is also written in an easy to read fashion so that patients and caregivers will also find it useful.It covers a wide range of topics on the Diabetic Foot starting with an Introductory Section on "Overview of Diabetes". Topics include 'What is Diabetes?', 'Complications of Diabetes' and 'Management of Diabetes'. The section on "Basic Science of Diabetic Foot" covers Anatomy, Biomechanics and Pathogenesis: the Diabetes Foot Triad of Neuropathy, Vasculopathy and Immunopathy. Other Sections include Classification, Clinical Presentation and Treatment.A highlight of the book is the large "Guide to Operative Surgery" section. This section covers Major Amputations, Minor Amputation and other Diabetic Foot Surgeries. The latter details Surgical Debridement and Split Skin Grafting - two of the commonest operations performed. This operative manual is also useful to residents and registrars.The section on Wound Care has also been carefully assembled to meet the needs of nurses, podiatrists and general practitioners, performing day to day dressing of diabetic wounds. It focuses on the use of New Generation Dressings including Silver and Iodine Dressings and Advances in Wound Healing. Patients and Care-givers will also find this useful.The last section "A Patient's Guide" is especially written to benefit patients and care-givers. It includes 'Care of Diabetes', 'Care of the Foot', 'Choosing your own Footwear', 'Doing your own Dressing' and 'Rehabilitating your Below Knee Amputation'.Finally, the Appendix includes details of the formation of NUH Diabetic Foot Team, Asia Pacific Association of Diabetic Limb Problems and the ASEAN Plus Expert Group Forum on the Management of Diabetic Foot Wounds.

An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease.

This book provides a concise, state-of-the art review of the surgical treatment of metabolic syndrome and diabetes mellitus. The volume reviews what current practices in surgery and metabolic syndrome and diabetes including the biohormonal effects of the different surgeries. Isolating the effects of the different procedures is critical to the decision tree for type of procedure selected for an individual patient. Specifically for diabetes, this textbook will provide a guide for practitioners to a tailored approach to the treatment. Areas of ongoing research that highlight the minimally invasive approach as well as incorporating what we know of the biochemical results of surgery are presented. Results of established weight loss procedures and ongoing trials are juxtaposed against some of the more novel techniques to ascertain a best practice. Metabolic Surgery and the Surgical Treatment of Diabetes serves as a very useful resource for physicians and researchers dealing with, and interested in, this rising epidemic of metabolic syndrome and diabetes. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Part of the Paediatric Psychology series Children and young people are increasingly among those being diagnosed with diabetes. However in the UK only 1 in 6 children succeed in controlling their diabetes successfully, despite support from parents and professionals. This enlightening new book is a comprehensive account of diabetes and the complex medical and psychosocial factors that influence metabolic control in children and young people. It presents a series of evidence-based and accessible educational, psychological and social approaches to increase specialist knowledge, promote positive attitudes, enhance patient care and create appropriate healthcare environments. The book offers an easy-to-comprehend approach to clinical care and includes practical tools for assessment for all healthcare professionals throughout the text. Featuring contributions from a number of international experts in the field, this thorough and wide-ranging guide is informative reading for all students, academics and professionals with an interest in paediatric psychology and health.

This new volume provides a plethora of new information about potential medicinal herbs and their usefulness in treating diabetes and neurological diseases. Most large multinational companies are interested and engaged in the commercialization of herb-based formulations, and consumers continue to seek natural-based therapies. Herbs for Diabetes and Neurological Disease Management provides insight into plant-based novel molecules targeted for diabetes and neurological disorders. It looks at a selection of herbs that have proven effective in the management of diabetes and neurological disorders, including migraine, epilepsy, memory disorders, depression, and more. Divided into ten chapters focusing on diabetes and its macro- and microvascular complications (migraine, epilepsy, memory disorders, depression and other neuropsychiatric disorders), this book is structured to provide a source of reliable information and enrich the knowledge of readers. Each chapter briefly explains the epidemiology and pathophysiology of the disease state and the possible role of herbal drugs in the prevention of the particular disease. The reported pharmacological activities and possible mechanism of action of herbal drugs are also discussed in detail, which makes this book informative and unique. This new volume will be a reliable reference complementing the substantial information on the use of herbal drugs in diabetes and neurological disorders that serve as the pillars of drug discovery and development.

Key Features * Details the latest diagnostic tests and treatments of diabetes and its complications, useful for ready reference by students, physicians, and healthcare professionals. * Explains how heart failure and stroke are deadly complications of diabetes along with kidney failure and life-threatening infections. * Establishes how cancer is linked to diabetes - a fact many people are not aware of - the book details the 6 types of cancer that may result from the disease, along with an individualized focus on the different "areas" of complications that occur from diabetes. * Discusses the effect of diabetes upon the minds of patients, in relation to depression, anxiety, panic, PTSD, eating disorders, delirium, and dementia.

This book addresses diabetic retinopathy, an eye disease that remains one of the main causes of vision loss if not diagnosed and managed properly. It aims to cover the entire spectrum of the disease by describing its clinical identification and characterization, pathophysiology, epidemiology, and medical and surgical management. Diabetic Retinopathy also offers a complete overview of the present understanding of diabetic retinopathy, covering current practice but also including original contributions that offer novel perspectives for looking at and addressing this disease.

The author has dedicated his lifetime to the study of diabetic retinal disease and has organized this book around his personal experience but at the same time giving the necessary information for updated management of diabetic retinopathy. Diabetic Retinopathy will be especially useful for postgraduate students in diabetology, retina specialists and researchers.

While nutrition is central to the management of diabetes, there is no one "diabetic diet". Nutritional prescriptions depend on the type of diabetes, food preferences, lifestyle, treatment regimen, comorbidities, state of health, and the route of caloric administration. Nutritional Strategies for the Diabetic/Prediabetic Patient is a comprehensive reference aimed at advancing physicians' knowledge of nutrition in relation to diabetes, allowing them to provide evidence-based recommendations for their diabetic patients. It also provides dietitians and diabetic educators with an in-depth understanding of the pathophysiology and medical treatment of diabetes. Written by scientists, clinicians, registered dietitians, and certified diabetes educators, this book reviews the molecular mechanisms of disease and drug therapy. It also provides recommendations for management with the level of evidence indicated where appropriate. In areas where little research data is available, the editors present recommendations based on extensive clinical experience. The book places particular focus on the synchronization of nutrient intake with medications, and provides unique clinical management tools, along with details of their ability to be replicated for patient use. To facilitate accessibility, it features evidence-based technical reviews of clinical literature and includes numerous tables and figures, with color photos of wound healing stages. Addressing all aspects of nutrition in adult diabetic and prediabetic patients, Nutritional Strategies for the Diabetic/Prediabetic Patient is an important referencefor those concerned with the dietary management of this disease.

Defeat your Insulin Resistance and change your life with an easy-to-follow plan and 75 recipes for a healthier you. It's proven that a healthy lifestyle can dramatically reduce your chances of diabetes, heart disease, and other illnesses. But where should you start? Americans are slowly becoming ill from impaired glucose metabolism that manifests itself as a debilitating illness or chronic condition. You may try to manage one problem after another diuretics to treat blood pressure, statins to lower cholesterol, metformin and insulin to treat diabetes--without fully realizing that the root of these issues is insulin resistance which revs up inflammation, damages the immune system, and disrupts the whole hormonal/chemical system in the body. It's time to feel better and get healthy by following a simple step-by-step plan to a healthy lifestyle. Rob Thompson, MD and Dana Carpender create the ultimate dream team in your journey to wellness. The Insulin Resistance Solution offers a step-by-step plan and 75 recipes for reversing even the most stubborn insulin resistance. The Program: - Reduce Your Body's Demand for Insulin: This is the stumbling block of many other plans/doctor recommendations. Even "healthy" and "moderate" carb intake can continue to fuel insulin resistance. - Fat is Not the Enemy: Stop Worrying about Fat, Cholesterol, and Salt - Exercise--the RIGHT way: - Use Carb Blockers: Eat and Supplement to Slow Glucose Digestion and Lower Insulin Levels - Safe, Effective Medication"

Diabetic Neurology offers a unique focus on the broad neurological complications of diabetes, bridging the clinical divide between diabetology and neurology with a practitioner-friendly guide for the recognition, investigation and management of diabetic patients with neurological disease.

This book provides a comprehensive, practical review of the problems encountered at the interface of diabetes and neurology. The point form format facilitates a thorough summary of the diabetological and neurological approach to patients and their related disease states.

The authors of this book bring together their expertise in these shared fields to address the problems neurologists may encounter in diabetic patients and the important neurological issues to consider in diabetes clinics. The emphasis is on adult patients and some topics are deliberately covered in more than one section, depending on the context of the discussion.

The book s three sections provide:

* An overview of diabetes care directed towards neurologists and of neurological basics directed towards diabetologists
* A summary of various neurological presentations, both common and serious, which both specialties must be cognizant of
* A discussion of rare conditions, their neurological and diabetic complications

This book is a comprehensive and useful reference for diabetologists, endocrinologists, internists and neurologists.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life.
This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation.

Recent research in diabetes has proven Type 1 diabetes is no longer only a juvenile disease. It has been projected adult Type 1 diabetes will increase 40% from 1997-2010, and as our understanding of the pathogenesis of Type 1 and Type 2 diabetes grows - it is apparent that some cases previously classified as Type 2 are actually adult onset Type 1 diabetes. This volume is the first to focus exclusively on Type 1 diabetes in adults, seeks to clarify the complexities by explaining latest concepts in the pathophysiology and management of the disease, and to assist clinicians in the optimal utilization of cutting edge technology, therapeutics, and management strategies available to them.