Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency

This book provides a concise, state-of-the art review of the surgical treatment of metabolic syndrome and diabetes mellitus. The volume reviews what current practices in surgery and metabolic syndrome and diabetes including the biohormonal effects of the different surgeries. Isolating the effects of the different procedures is critical to the decision tree for type of procedure selected for an individual patient. Specifically for diabetes, this textbook will provide a guide for practitioners to a tailored approach to the treatment. Areas of ongoing research that highlight the minimally invasive approach as well as incorporating what we know of the biochemical results of surgery are presented. Results of established weight loss procedures and ongoing trials are juxtaposed against some of the more novel techniques to ascertain a best practice. Metabolic Surgery and the Surgical Treatment of Diabetes serves as a very useful resource for physicians and researchers dealing with, and interested in, this rising epidemic of metabolic syndrome and diabetes. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

This new volume provides a plethora of new information about potential medicinal herbs and their usefulness in treating diabetes and neurological diseases. Most large multinational companies are interested and engaged in the commercialization of herb-based formulations, and consumers continue to seek natural-based therapies. Herbs for Diabetes and Neurological Disease Management provides insight into plant-based novel molecules targeted for diabetes and neurological disorders. It looks at a selection of herbs that have proven effective in the management of diabetes and neurological disorders, including migraine, epilepsy, memory disorders, depression, and more. Divided into ten chapters focusing on diabetes and its macro- and microvascular complications (migraine, epilepsy, memory disorders, depression and other neuropsychiatric disorders), this book is structured to provide a source of reliable information and enrich the knowledge of readers. Each chapter briefly explains the epidemiology and pathophysiology of the disease state and the possible role of herbal drugs in the prevention of the particular disease. The reported pharmacological activities and possible mechanism of action of herbal drugs are also discussed in detail, which makes this book informative and unique. This new volume will be a reliable reference complementing the substantial information on the use of herbal drugs in diabetes and neurological disorders that serve as the pillars of drug discovery and development.

This issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with essential updates on treatment of type 1 diabetes, with an eye toward future trends and developments.? The Guest Editors brought together a remarkable group of notable authors, such as Paul Robertson, President of the National Diabetes Association.? Topics covered include epidemiology; economics; contemporary management; inpatient management; update on insulin pumps and continuous glucose monitoring systems; update on studies aimed at interdicting and preventing type 1 diabetes; advances in the prediction, natural history, and mechanisms leading to type 1 diabetes; complications; hypoglycemia in type 1 diabetes; new lessons from animal models; the role of the gut in the genesis of type 1 diabetes and other autoimmune diseases; and an update on transplantation for reversing type 1 diabetes.

Diabetic Neurology offers a unique focus on the broad neurological complications of diabetes, bridging the clinical divide between diabetology and neurology with a practitioner-friendly guide for the recognition, investigation and management of diabetic patients with neurological disease.

This book provides a comprehensive, practical review of the problems encountered at the interface of diabetes and neurology. The point form format facilitates a thorough summary of the diabetological and neurological approach to patients and their related disease states.

The authors of this book bring together their expertise in these shared fields to address the problems neurologists may encounter in diabetic patients and the important neurological issues to consider in diabetes clinics. The emphasis is on adult patients and some topics are deliberately covered in more than one section, depending on the context of the discussion.

The book s three sections provide:

* An overview of diabetes care directed towards neurologists and of neurological basics directed towards diabetologists
* A summary of various neurological presentations, both common and serious, which both specialties must be cognizant of
* A discussion of rare conditions, their neurological and diabetic complications

This book is a comprehensive and useful reference for diabetologists, endocrinologists, internists and neurologists.

People with diabetes are two to four times more likely to develop cardiovascular disease.? Insulin resistance, which leads to diabetes in 1 in 4 people who have it, affects 60 million Americans and is also a cardiovascular disease risk factor.? It is important for cardiologists to understand the reasons why diabetes and insulin resistance cause increased cardiovascular risk so they can help their patients control these risk factors.

Emphasizing a team approach that includes the practicing podiatrist, endocrinologist, diabetologist, vascular surgeon, orthopedist, and infectious disease specialist, The High Risk Diabetic Foot provides a thorough and detailed resource on the management of complex diabetic foot problems. This comprehensive text is an essential tool that will enable physicians to reduce infections and amputations through careful examination, diagnosis, treatment, and prevention.

Key features in The High Risk Diabetic Foot include:

• A full section devoted to the prevention of amputation
• High-quality images for accurate diagnosis
• Chapters organized by epidemiology, classification and staging, diagnosis, special studies, and medical and surgical management
• Summary tables and flow charts for quick reference
• A discussion of the co-morbidities associated with diabetic foot pathology, including sensory neuropathy, painful neuropathy, peripheral vascular disease, food wounds, and more
• Identification of the level of medical evidence associated with treatment recommendations

Diabetes Digital Health and Telehealth explains, from technologic, economic and sociologic standpoints how digital health and telehealth have come to dominate the management of diabetes. The book also includes information on improved telemedicine tools and platforms for communicating with patients, reviewing medical records, and interpreting data from wearable devices. In addition, evolving wearable sensors such as continuous glucose monitors, closed loop automated insulin delivery systems, cuffless blood pressure monitors, exercise monitors and smart insulin pens are covered.

The incidence and prevalence of type 2 diabetes mellitus have increased dramatically in modernized and developing nations over the past few decades. Thoroughly revised and expanded, this Second Edition responds to the epidemic and supplies a current overview and guide to the management of diabetes in the modern healthcare environment. This Second Edition offers a current perspective on diabetes demographics, epidemiology, pathophysiology, disease monitoring, and approaches to glucose control, and supplies new chapters by world-renowned experts on non-pharmacological management options, complications of the skin and urogenital function, related macrovascular conditions, coronary heart disease, stroke, and peripheral vascular disease, and rare forms of diabetes, PCOS, and NASH.

While nutrition is central to the management of diabetes, there is no one "diabetic diet". Nutritional prescriptions depend on the type of diabetes, food preferences, lifestyle, treatment regimen, comorbidities, state of health, and the route of caloric administration. Nutritional Strategies for the Diabetic/Prediabetic Patient is a comprehensive reference aimed at advancing physicians' knowledge of nutrition in relation to diabetes, allowing them to provide evidence-based recommendations for their diabetic patients. It also provides dietitians and diabetic educators with an in-depth understanding of the pathophysiology and medical treatment of diabetes. Written by scientists, clinicians, registered dietitians, and certified diabetes educators, this book reviews the molecular mechanisms of disease and drug therapy. It also provides recommendations for management with the level of evidence indicated where appropriate. In areas where little research data is available, the editors present recommendations based on extensive clinical experience. The book places particular focus on the synchronization of nutrient intake with medications, and provides unique clinical management tools, along with details of their ability to be replicated for patient use. To facilitate accessibility, it features evidence-based technical reviews of clinical literature and includes numerous tables and figures, with color photos of wound healing stages. Addressing all aspects of nutrition in adult diabetic and prediabetic patients, Nutritional Strategies for the Diabetic/Prediabetic Patient is an important referencefor those concerned with the dietary management of this disease.

Recent research in diabetes has proven Type 1 diabetes is no longer only a juvenile disease. It has been projected adult Type 1 diabetes will increase 40% from 1997-2010, and as our understanding of the pathogenesis of Type 1 and Type 2 diabetes grows - it is apparent that some cases previously classified as Type 2 are actually adult onset Type 1 diabetes. This volume is the first to focus exclusively on Type 1 diabetes in adults, seeks to clarify the complexities by explaining latest concepts in the pathophysiology and management of the disease, and to assist clinicians in the optimal utilization of cutting edge technology, therapeutics, and management strategies available to them.

Psychosocial issues have long been acknowledged to have a crucial role in the successful treatment of people with diabetes. An understanding of these issues can enable health care professionals to assist their patients effectively. The second edition of the acclaimed title "Psychology in Diabetes Care" gives background information and practical guidelines needed by healthcare professionals to address the cognitive, emotional and behavioural issues surrounding diabetes management.

The book bridges the gap between psychological research on self-care and management of diabetes, and the delivery of care and services provided by the diabetes care team.

Written jointly by psychologists active in diabetes research and practising clinicians, "Psychology in Diabetes Care, Second Edition" provides a practical evidence-based approach to intervention in diabetes care.

Last year, the National Audit Office reported that levels of obesity in the UK have tripled over the last 20 years. This makes the British among the fattest nations in Europe and, if nothing is done to halt the epidemic, it is feared that levels will soon reach those in the US where one person in every four is obese. Every year tens of thousands of people in the western world are dying prematurely from heart disease, stroke and diabetes - all of them closely linked to obesity.
Obesity is a disease. It is the expression of a classic interaction between nature and nurture. What are the factors responsible for its development? Are we becoming more and more a nation of couch potatoes, or are we just eating too much? Do fat children become fat adults? Can anything be done to halt the obesity epidemic?
This collection of essays, based on presentations made at a national symposium on obesity, is aimed at the generalist with an interest in managing obesity and its outcomes, whether general practitioner, community nurse, dietician or hospital clinician. Its purpose is to highlight the causes and consequences of obesity and to bring modern understanding to the treatment of a problem that is still heavily stigmatised. The authors offer a wide-ranging perspective of obesity as a global problem and explore its devastating metabolic, social and political impact.
What is increasingly clear is that the seeds of many of these adult diseases are sown in childhood. The prevention of adult obesity has thus become a major challenge for the paediatrician.

Gestational Diabetes Mellitus is becoming an increasingly prevalent disease as obesity and other chronic diseases are on the rise. It requires careful and informed clinical management as the care received during pregnancy affects not only perinatal health but the risk of developing type 2 diabetes even decades into the future, in both the mother and the child.From epidemiology and pathophysiology to diagnosis and management, covering recent breakthroughs in research and up-to-date developments in clinical practice, Gestational Diabetes During and After Pregnancy offers the reader a comprehensive and current look at Gestational Diabetes. Anyone involved in the research, public health or clinical aspects of Gestational Diabetes will find this volume a valuable aid in consolidating all recent developments regarding this disease.

(Diabetes Forum Series; Vol. 3)

Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.

Contents:
1. What do gap junctions do anyway? 2. Cardiovascular gap junctions: Functional Diversity, complementation and specialization of connexins 3. Endothelium and smooth muscle pathways for conduction along resistance microvessels 4. Membrane potential and calcium responses evoked by acetylcholine in submucosal arterioles of the guinea-pig small intestine 5. The effects of ouabain, 18a-glycyrrhetinic acid and connexin-mimetic peptides on intercellular communication in cells expressing a Cx43-GFP chimeric protein 6. Role of gap junctions in endothelium-dependent hyperpolarizations 7. Heterogeneity of EDHF-type relaxations of rabbit and rat arteries analysed with peptides homologous to the extracelluar loops of connexins 37, 40 and 43 8. Myoendothelial and circumferential spread of endothelium-dependent hyperpolarization in coronary arteries 9. Direct myoendothelial contact in human pulmonary microvessels 10. Role of gap junctional communication in EDHF-mediated responses and mechanisms of K-induced dilatations 11. Comparison of alpha and beta isoforms of glycyrrhetinic acid and carbenoxolone as inhibitors of EDHF-type relaxation 12. Inhibitory effect of 18-beta-glycyrrhetinic acid on the relaxation induced by acetylcholine in the rat aorta 13. A central role for endothelial cell potassium channels in EDHF-mediated responses 14. Could the EDHF be K in porcine coronary arteries? 15. Nitro-L-arginine/indomethacin-resistant relaxations to acetylcholine in small gastric arteries of the rat: Effect of ouabain plus Ba2+ and relation to potassium ions 16. Effects of barium, ouabain and K+ on the resting membrane potential and endothelium-dependent responses in rat arteries 17. EDHF and potassium: Blockade of chloride channels reveals relaxations of rat mesenteric artery to potassium 18. Cytochrome P450 2C is a source of EDHF and reactive oxygen species in the porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary arteries and up-regulates the expression of cytochrome P450 2C9 20. An arachidonic acid metabolite(s) produced by the endothelial cytochrome P450 isoform, CYP3A4, relaxes the lingual artery of the monkey via K+ channel opening 21. EDHF-mediated responses induced by bradykinin in the porcine coronary artery 22. Epoxyeicosatrienoic acid release mediates nitric oxide-independent dilatation of rat mesenteric vessels 23. Epoxyeicosatrienoic acid and endothelium-dependent hyperpolarization in porcine coronary arteries 24. Lipoxygenase-derived metabolites of arachidonic acid are not involved in the endothelium-dependent hyperpolarization to acetylcholine in the carotid artery of the guinea-pig 25. Cytochrome P450 isoforms in the brain encode cell specific hyperpolarizing factors with a common mechanism of action 26. Expression of recombinant cytochrome P450 epoxygenase in rat brain 27. Identification of 11, 12, 15-trihydroxyeicosatrienoic acid as the mediator of acetylcholine- and arachidonic acid-induced relaxations in the rabbit aorta 28. Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice 29. Components of the potassium currents underlying the actions of endothelium- derived hyperpolarizing factor in arterioles 30. Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse 31. Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS-/- and +/+ mice 32. EDHF, which is not NO, is a major endothelium-dependent vasodilator in mice 33. Prostacyclin and iloprost in the isolated carotid artery of the guinea pig 34. Role of charybdotoxin/apamin sensitive K+ Ca channels in pulsatile perfusion- mediated coronary vasodilatation in vivo 35. Essential role of estrogen in the EDHF-mediated responses of mesenteric arteries from middle-aged female rats: Possible contribution of gap junctional protein connexin 43 36. Endothelium-derived hyperpolarizing factor (EDHF) and utero-feto-placental circulation in the rat 37. Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite impairment of the nitric oxide pathway in porcine coronary arteries with regenerated endothelium 38. Mechanisms underlying the vasodilatation caused by bradykinin in essential hypertensive patients 39. Influence of diabetes on endothelium-dependent responses in mesenteric and femoral arteries of rats 40. Folate restores the NO synthase- and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes 41. Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries 42. Critical limb ischemia results in different types of endothelial dysfunction depending on the vascular bed studied 43. Potentiated EDHF-mediated dilatations in the rat middle cerebral artery following ischemia/reperfusion 44. The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aorta is resistant to ionized radiation 45. Inhibition of converting enzyme prevents the age-related decline in endothelium-dependent hyperpolarization 46. Effects of a converting enzyme inhibitor, an AT1-receptor antagonist and their combination on endothelial dysfunction in hypertension 47. EDHF: Gap junction or chemical? And many other questions

The bestselling, big-hearted and down-to-earth chefs, The Hairy Bikers, return with 80 of their very best Dieter recipes. Contains previously published recipes - brought together in a collection that's designed to help tackle type 2 diabetes for the first time.

In this paperback, first of a new healthy eating series, the Hairy Bikers prove that you can still eat your favourite foods while staying healthy and losing weight. With their delicious, low-cal versions of traditional classics and family favourites, the Bikers take the deprivation out of restrictive diets and are here to help you shift the pounds.

This book is full of information to digest and dieting hits to enjoy. The Bikers also share their own personal stories of their battles against type 2 diabetes, and hope to inspire readers as they start their own weight loss journey.

Whether you've been struggling with type 2 diabetes for years or have recently been diagnosed, there's no better time to take action and make a change.

This book is a how-to manual for practicing physicians and health care providers, nurse educators, nutritionists, and physicians in training in the management of persons with diabetes mellitus. Experts with strong clinical and teaching backgrounds provide up-to-date recom-mendations and rationale of the most effective diagnostic and therapeutic approaches to diabetes mellitus and its multiorgan micro- and macrovascular complications for patients of all ages. Gives five practical guidelines for nutrition therapy that supplies realistic recommendations! With contributions from nearly 60 clinicians who reveal a constellation of disorders with different signs, symptoms, clinical characteristics, and therapies, Medical Management of Diabetes Mellitus -reviews the autoimmune process and genetics of type 1 and type 2 diabetes -offers an overview of the medications that impair glucose metabolism causing hypo- or hyperglycemia -covers pathogenesis, clinical presentation, and diagnosis with specialized laboratory tests -surveys therapeutic modalities, their mechanisms of action, and rationale for use -focuses on outcomes and how they are tracked -stresses early detection and therapy of end-organ complications -discusses the effect of intensive diabetes management on reducing retinopathy, nephropathy, and neuropathy -considers incorporating psychiatric techniques into the treatment of diabetes -compares and contrasts diabetes in children, adults, and the elderly -and more! Containing over 850 references, tables, drawings, and photographs, Medical Management of Diabetes Mellitus is a cross-disciplinary reference perfect for family practice physicians, internists, pediatricians, endocrinologists, pharmacologists, nutritionists, physiologists, dietitians, obesity specialists, psychiatrists, and medical school students in these disciplines.

An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.
Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

Over 100 delicious recipes suitable for people with diabetes -- and those without! A healthy diet should be an important feature of our daily life and include a variety of foods from all food groups -- plenty of vegetables and fruits, breads and cereals, some dairy foods, lean meat and/or meat alternatives, and a small amount of polyunsaturated and monounsaturated fats. All recipes in this book satisfy the nutritional guidelines suitable for diabetes and overall healthy eating. Unless otherwise stated, the recipes use wholegrain cereal products, low-fat dairy products, minimal sugar and polyunsaturated and monounsaturated fats. In the interests of health and diabetes management, each recipe provides a nutritional analysis per recipe and serve for: Kilojoules; total fat; saturated fat; fibre; carbohydrates; sodium; protein.

The increasing prevalence of diabetes mellitus world-wide is an issue of major socio-economic concern. Scientific interest in plant-derived medicine is steadily rising, yet there is often a wide disparity in the caliber of information available. A detailed compilation of scientific information from across the globe, Traditional Medicines for Modern Times: Antidiabetic Plants highlights the potential role of dietary and medicinal plant materials in the prevention, treatment, and control of diabetes and its complications. The book not only describes plants traditionally used to treat diabetes, but evaluates the scientific studies on these plants and describes in vitro, in vivo, and clinical methods for their investigation. It examines the theory that changes in dietary patterns from traditional plant foodstuffs containing beneficial components, to richer, more processed "junk" food is responsible for the increased prevalence of diabetes worldwide.The book begins with an introduction to the disease diabetes mellitus written by a consultant physician and an up-to-date, detailed summary table and discussion of scientifically screened antidiabetic plants compiled by authors from the Jodrell Laboratories, Royal Botanic Gardens, Kew, UK. The next chapters provide an outline of clinical, in vivo, and in vitro methods for assessing antidiabetic activity of plant materials, followed by descriptions of traditional plant remedies used in Asia, the Americas, Africa, Europe, and Australia written by an international group of authors active in antidiabetic plant research. The final chapters emphasize the role of particular phytochemical groups in the treatment or prevention of diabetes. By documenting both traditional and scientifically derived knowledge, Traditional Medicines for Modern Times: Antidiabetic Plants brings us closer to the translation of traditional knowledge into new methods for treatment of this important disease.

This important text will be the first devoted to a detailed analysis of immunotherapy as it applies to Type I diabetes and the pathogenesis and therapy of other specific autoimmune diseases (including uveitis, multiple sclerosis, myasthenia gravis, Cogan's syndrome, Graves' ophthalmopathy, and gonadal disorders).

When he was diagnosed with both high blood pressure and type 2 diabetes Dr Kongnyuy was initially shocked and depressed at the life-sentence of ill health, medication and restricted lifestyle he felt he'd been handed. But with the support of his family and his knowledge of medical science, he brought his research training to bear on the problem - if these are lifestyle conditions then can lifestyle not reverse them? Conducting a series of experiments on himself that involved changes in diet and lifestyle over several years, he identified what did and did not work for him. Both his method for finding what suits us individually, and his findings as to what returned him to health, will provide invaluable guidance to all those seeking to reverse type 2 diabetes and hypertension.