Global Health Complications of Obesity presents a valuable resource for research scientists and clinicians by covering the burden of obesity and related diseases and serving as a starting point for in-depth discussions in academic settings and for obesity-treatment specialists. Obesity is associated with a statistically higher risk of heart disease, hypertension, insulin resistance, type 2 diabetes and many other diseases. This succinct resource focuses on the current data, research and management of obesity. It is essential reading for healthcare professionals, endocrinologists, nutritionists, public health students and medical students.

Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin- signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.

This issue of Physician Assistant Clinics, Guest Edited by Kim Zuber, PA-C and Jane S. Davis, CRNP, DNP, is devoted to Diabetes. Articles in this outstanding issue include: A Century of Discovery: The Centennial of Insulin; What it is and How we know: Diabetes in the 21st Century; The Ominous Octet and other Scary Diabetes Stories; Putting the Diabetes Patient in Charge; Diabetes: Counting Carbs Instead of Pennies; Non-insulin Therapy for Diabetes; Pens and Needles: Insulin Therapy for Diabetes; Managing Diabetes in the Digital Age; When Crisis Strikes: The acute complications of diabetes; Living Day to Day: Chronic Complications in Diabetes; Sugar Babies: Diabetes in the Pediatric Population; And Baby Makes 2: Gestational Diabetes; The Boomers Come of Age: Elderly and Frail Diabetes Patients; The Rising Price of Sugar; and The Future of Diabetes. A CME program is also available to subscribers of Physician Assistant Clinics.

This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Grazia Aleppo, will cover key topics in Technology in Diabetes. This issue is one of four selected each year by our series consulting editor, Dr. Adriana G. Ioachimescu. Topics discussed in this issue will include: Evolution of Diabetes Technology, Diabetes Technology in children, Diabetes Technology in adults with type 1 and type 2 Diabetes, Benefits and challenges of Diabetes Technology use in older adults, Integration of Diabetes Technology in Clinical Practice, Diabetes Technology in the inpatient setting for management of hyperglycemia, Standardization of CGM reports, Diabetes Technology and Exercise, Psychosocial Aspects of Diabetes Technology use, Automated insulin delivery, and Glucagon, among others.

Pancreas transplantation has rapidly moved from an experimental procedure associated with high rates of morbidity and mortality to a mainstream technique with excellent patient and graft survival. Over 30,000 pancreas transplants have already been performed. The value of pancreas transplantation however must be balanced against the risk of the operative procedure and the innovative long-term immunosuppressive therapy. The indications for this procedure and the selection of the patients are critical to ensure low mortality and any improvements in quality of life.
This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation.

Adopting an anthrozoological perspective to study the participation of non-human animals in regimes of care, this book examines the use of canine scent detection to alert 'hypo-unaware' individuals to symptoms of human chronic illness. Based on ethnographic research and interviews, it focuses on the manner in which trained assistance dogs are able to use their sense of smell to alert human companions with Type 1 diabetes to imminent hypoglycaemic episodes, thus reducing the risk of collapse into unconsciousness, coma or, at worst, death. Through analyses of participant narrations of the everyday complexities of 'doing' diabetes with the assistance of medical alert dogs, the author sheds light on the way in which each human-canine dyad becomes acknowledged as a team of 'one' in society. Based on the concept of dogs as friends and work colleagues, as animate instruments and biomedical resources, the book raises conceptual questions surrounding the acceptable use of animals and their role within society. As such, this volume will appeal to scholars across the social sciences with interests in human-animal interactions and intersections. It may also appeal to healthcare practitioners and individuals interested in innovative multispecies methods of managing chronic illness.

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

With the increasing incidence of Type 2 diabetes in the adult population and the realization that this is a vascular disease and a major coronary risk factor, Professor Betteridge has chosen fifty diabetologists to contribute a case which has had an effect on their clinical practice. Both Types 1 and 2 diabetes are included, along with other forms of diabetes, eg gestational. Each case is presented in the same format. The various cases are informative and educational and should provide the reader with a sounder knowledge of patient and disease types.

There has been a recent surge of new data on the subject of exercise and sport in type I diabetes, as well as great interest from the multidisciplinary healthcare teams looking after such patients. Providing advice and support to enable athletes to manage their diabetes during and after sport is an essential part of diabetes care. Type I Diabetes: Clinical Management of the Athlete outlines best practice and scientific progress in the management of people with type I diabetes who undertake a sport at any level. The book explores endocrine response to exercise, hypoglycemia and dietetics in the diabetic patient, and provides real-life examples of type I diabetes management at the professional athlete level. It is the first source of reference for specialists in diabetes when seeking advice on how to manage their patient and provides practical advice for equipping the type I diabetes patient with the ability to fulfill their sporting potential.

The Forensic Aspects of Hypoglycaemia succinctly covers the medicolegal considerations of hypoglycaemia in a variety of scenarios including driving fatalities, petty crime, homicide and suicide. Covering the definitions and diagnosis of hypoglycaemia to its bearing on criminal behavior, this book draws on the author's extensive experience and contains a wealth of information for physicians and lawyers, including cases from the author's past and notable cases in the public domain.

In the field of immunology, type 1 diabetes has become one of the major areas of investigation with studies that span from characterization of key molecules to trials for the prevention of the disease.
Type 1 Diabetes: Molecular, Cellular and Clinical Immunology communicates both the background and the most recent understanding of this disorder, which will almost certainly be central to elucidating the etiology of autoimmunity, and in particular of organ specific autoimmunity. The book covers immunogenetics, immunopathogenesis, epidemiology, disease prediction and clinical application of current knowledge.
Both scientists seeking to understand and prevent type 1 diabetes/autoimmunity as well as physicians caring for families with type 1 diabetes will be interested in this book.

Few complications of systemic diseases are better understood than diabetic nephropathy. In large part, progress in this area is due to Carl Erik Mogensen's steadfast preoccupation over more than three decades with the disorder's epidemiology, pathogenesis, pathophysiology, clinical diagnosis and evolving strategies of management. Though he sparked progress in each of these areas, he generously opens the forum of discussion to many expert contributors to this latest and most comprehensive edition of this exemplary textbook. In eliciting all relevant and up-to-date views, the reader, whether internist, pediatrician or specialist in endocrinology or nephrology, is assured a thorough review of the entire subject and in a format which is exceptionally well-written, well-illustrated and easy to read. Each of the prior editions have been an essential resource for my own work in this field and the 5th edition will no doubt continue to provide the information I and others will require to move forward in the years ahead. If only the other renal diseases were as masterfully synthesized, how much easier our task would be of achieving a comprehensive vision of all else in clinical nephrology. Barry M. Brenner, M.D., Samuel A. Levine Professor of Medicine, Harvard Medical School

Defeat your Insulin Resistance and change your life with an easy-to-follow plan and 75 recipes for a healthier you. It's proven that a healthy lifestyle can dramatically reduce your chances of diabetes, heart disease, and other illnesses. But where should you start? Americans are slowly becoming ill from impaired glucose metabolism that manifests itself as a debilitating illness or chronic condition. You may try to manage one problem after another diuretics to treat blood pressure, statins to lower cholesterol, metformin and insulin to treat diabetes--without fully realizing that the root of these issues is insulin resistance which revs up inflammation, damages the immune system, and disrupts the whole hormonal/chemical system in the body. It's time to feel better and get healthy by following a simple step-by-step plan to a healthy lifestyle. Rob Thompson, MD and Dana Carpender create the ultimate dream team in your journey to wellness. The Insulin Resistance Solution offers a step-by-step plan and 75 recipes for reversing even the most stubborn insulin resistance. The Program: - Reduce Your Body's Demand for Insulin: This is the stumbling block of many other plans/doctor recommendations. Even "healthy" and "moderate" carb intake can continue to fuel insulin resistance. - Fat is Not the Enemy: Stop Worrying about Fat, Cholesterol, and Salt - Exercise--the RIGHT way: - Use Carb Blockers: Eat and Supplement to Slow Glucose Digestion and Lower Insulin Levels - Safe, Effective Medication"

Today, there are more than 23 million diabetics in the United States and with that number expected to rise drastically over the next decade the nation is faced with a health crisis of epidemic proportions. For those personally afflicted by this debilitating disease the everyday challenges can often seem overwhelming. In Diabetes and You, Dr. Naheed Ali offers both hope and empowerment to these sufferers and their families. Using the latest findings in clinical and physician studies, this book helps diabetics to successfully combat this disease and its symptoms on a number of fronts. Ali offers not only a hopeful perspective but also new and practical ways to confront and live with this condition. The full scope of diabetes-from its causes to its prevention and from the newest methods of treatment to the effects of diet and mental heath-is introduced in simple, non-technical language accessible to all readers. Diabetes and You is both state-of-the-art and user friendly, and emphasizes a whole body approach to this increasingly common, high-profile disease. As a physician and medical lecturer with a long association within the health care industry, Ali presents detailed advice to make coping with diabetes much simpler and easier than ever before. The reader is introduced to groundbreaking information on the risk factors associated with diabetes, the signs and symptoms, the different types of the disease, and how it can crop up in juvenile health. Diabetes and You will motivate diabetics to fight their condition in new and effective ways.

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

Prevention and treatment of cardiometabolic disorders by lifestyle management is the most understood and effective applications of this emerging field. The focus of this book on prediabetes, diabetes and cardiometabolic diseases is timely and will be a welcome addition to clinicians who wish to gain more knowledge and competence in the area. This book will focus on the metabolic syndrome, which is the largest non-communicable disease of our time, and lifestyle approaches that drastically reduce the risks and adverse effects of this condition. Presents a detailed review of clinical evidence and guide for implementation. Provides a toolkit to counter both the high cost of medications and the need to address metabolic disorders associated with insulin resistance early, before or simultaneous to when medications are indicated.

Diabetic Neurology offers a unique focus on the broad neurological complications of diabetes, bridging the clinical divide between diabetology and neurology with a practitioner-friendly guide for the recognition, investigation and management of diabetic patients with neurological disease. This book provides a comprehensive, practical review of the problems encountered at the interface of diabetes and neurology. The point form format facilitates a thorough summary of the diabetological and neurological approach to patients and their related disease states. The authors of this book bring together their expertise in these shared fields to address the problems neurologists may encounter in diabetic patients and the important neurological issues to consider in diabetes clinics. The emphasis is on adult patients and some topics are deliberately covered in more than one section, depending on the context of the discussion. The book's three sections provide: * An overview of diabetes care directed towards neurologists and of neurological basics directed towards diabetologists * A summary of various neurological presentations, both common and serious, which both specialties must be cognizant of * A discussion of rare conditions, their neurological and diabetic complications This book is a comprehensive and useful reference for diabetologists, endocrinologists, internists and neurologists.

Emphasizing a team approach that includes the practicing podiatrist, endocrinologist, diabetologist, vascular surgeon, orthopedist, and infectious disease specialist, The High Risk Diabetic Foot provides a thorough and detailed resource on the management of complex diabetic foot problems. This comprehensive text is an essential tool that will enable physicians to reduce infections and amputations through careful examination, diagnosis, treatment, and prevention. Key features in The High Risk Diabetic Foot include: A full section devoted to the prevention of amputation High-quality images for accurate diagnosis Chapters organized by epidemiology, classification and staging, diagnosis, special studies, and medical and surgical management Summary tables and flow charts for quick reference A discussion of the co-morbidities associated with diabetic foot pathology, including sensory neuropathy, painful neuropathy, peripheral vascular disease, food wounds, and more Identification of the level of medical evidence associated with treatment recommendations

Studies on Diabetes examines how increased oxidative and nitrosative stress - one of the leading causes of diabetes complications - pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease. Their contributions represent a wealth of knowledge on and research into how diabetes triggers metabolic abnormalities that lead to hyperactivation of cellular and mitochondrial pathways that ultimately result in oxidative and nitrosative stress that left un-neutralized, results in tissue damage. Each chapter provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease. Potential treatments for diabetes complications from animal models to the patient will also be discussed. This is essential reading for researchers and clinicians in endocrinology, diabetes, vascular disease and oxidative stress.

A hot topic with increasing importance

Integrating contemporary scientific developments with practical management

Written by leaders in the field of pediatric diabetes with extensive practical knowledge

In 1981, David Jenkins, Thomas Wolever, and colleagues introduced the concept of the glycemic index (GI) to differentiate carbohydrates based on the rate of blood glucose rise following their consumption. Although GI was first used in diet therapy for diabetes, research evidence has accumulated since then to thousands of publications from all over the world with applications for prevention and/or management of many diseases, as well as effects on physiological states and exercise. The Glycemic Index: Applications in Practice has gathered together, in an unbiased and critical way, all the evidence and research on GI, including diabetes, cardiovascular disease, cancer, obesity, polycystic ovary syndrome, pregnancy outcomes, sports performance, eye health, and cognitive functioning. It provides a detailed explanation on how to correctly measure a food's GI, how the GI of food products can be altered, as well as the use and misuse of GI labelling around the globe. The contributors are either pioneers or experts in the area of GI from all around the globe, including Australia, Canada, Europe, and the United States. The book is a valuable source of information for healthcare professionals of various disciplines, nutritionists, dietitians, food scientists, medical doctors, sports scientists, psychologists, public health (nutrition) policy makers, and students in these fields, as well as an important addition to university libraries.

Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed.Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs - many based on incretin action - have been added to the therapeutic armoury.Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice.Incretin Biology - A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject.

The role of diet in the prevention, control and treatment of diabetes continues to provide significant opportunity for non-pharmaceutical interventions for many of the over 20 million people who live with this disease. Looking beyond traditional dietary controls may lead to more effective, cost efficient, and flexible options for many patients.

Bioactive Food as Dietary Interventions for Diabetes is the only available scientific resource focused on exploring the latest advances in bioactive food research, and the potential benefit of bioactive food choice on the diabetic condition. Written by experts from around the world, it presents important information that can help improve the health of those at risk for diabetes and diabetes related conditions using food selection as its foundation.
Focuses on the role of bioactive foods in addressing pre-diabetes symptoms, their potential to complement other treatments for those suffering from diabetes and diabetic-related obesity and other health issuesDocuments foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathwaysIncludes insights from experts from around the world, providing global perspectives and options based on various regional foods

Examining the layers of meaning encoded in software and the rhetoric surrounding it, this book offers a much-needed perspective on the intersections between software, morality, and politics. In software development culture, evangelism typically denotes a rhetorical practice that aims to convert software developers, as well as non-technical lay users, from one platform to another (e.g., from the operating system Microsoft Windows to Linux). This book argues that software evangelism, like its religious counterpart, must also be understood as constructing moral and political values that extend well beyond the boundaries of the development culture. Unlike previous studies that locate such values in the effects of code in-use or in certain types of code like free and open source (FOSS) software, Maher argues that all code is meaningful beyond its technical, executable functions. To facilitate this analysis, this study builds a theory of evangelism and illustrates this theory at work in the proprietary software industry and FOSS communities. As an example of political liberalism at work at the level of code, these evangelical rhetorics of software construct competing conceptions of what is good that fall within a shared belief in what is just. Maher illustrates how these beliefs in goodness and justice do not always execute in replicable ways, as the different ways of decoding software evangelisms in the contexts of Brazil and China reveal. Demonstrating how software evangelisms exert a transformative force on the world, one comparable in significance to code itself, this book highlights the importance of rhetoric in even the most seemingly a-rhetorical of technical endeavors and foregrounds the crucial need for rhetorical literacy in the digital age.

The low-carb lifestyle continues to be a popular choice among those trying to lose weight through the ketodiet, resolve insulin resistance, and combat pre-diabetes and Diabetes. Those in the gluten-free and Paleo/Primal diet communities are also searching for recipes with that, help the gut, work with their lifestyle and benefit their health. Foods that are high in fat and low in carbs are, in some cases, just what the doctor ordered. Bestselling low-carb author and advocate, Dana Carpender, strips away the carbohydrates (grains and starches) and reveals 200 of her best ultra-low carb recipes for those who are looking to take their low-carb lifestyle to the next level. These recipes have been recipes updated to be Paleo/Primal-friendly, featuring no artificial sweeteners, gluten, or other processed ingredients. The official cookbook of HEAL Diabetes and Medical Weight Loss Centers, founded by Dr. Eric Westman, this book has 200 recipes to jumpstart your nutrition and get you on the path to a healthier, happier you.