This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.

Only comprehensive reference book on pressure ulcers and their management

Only book in its field endorsed by the European Pressure Ulcer Advisory Panel, the leading European authority on pressure ulcers

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few mad scientists searching for natural substrates.

Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajduszoboszlo, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research."

In this practical book, the authors of each chapter have synthesized the currently available evidence regarding specific issues in diabetes care. The chapters have been written by an interdisciplinary team of scientists and medical professionals. Such an approach emphasizes the need for collaboration in the care of any individual with diabetes and in the effort to find new therapies for the disease. This reference provides practical guidance in a single resource.

This is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The first section details the basic mechanism of autoimmunity and examines immunogenetic and environmental factors in autoimmunity. The next section examines autoimmune thyroid disease. The third section takes a look at Type 1 diabetes mellitus. In the final section, authors explain other autoimmune endocrinopathies.

This book addresses diabetes controversies, specifically in the management of etiology and the disease itself. Chapters also examine the complications associated with diabetes. The volume covers commonly accepted forms of therapies and complications, as well as new and emerging advances and therapies and inadequacies in several standard treatments. Comprehensive and timely, this book is an essential reference for those treating and researching diabetes.

A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.

The growing problem of diabetes presents difficult challenges for sufferers and for those in the healthcare professions, who are in the unenviable position of trying to convince patients to change their lifestyle "for their own good." Handbook of Diabetes Management provides practical knowledge and advice that can help you anticipate the challenges of working with these Patients. What's more, since the knowledge here is evidence-based, you can assure your patients that the guidelines you're presenting to them have been shown to be effective. This guide takes into account the complexity of the disease, the diversity of the populations it affects, and the continued improvement of care systems. It discusses the origins of diabetes and medication management and treatment, then presents advice based on the latest research findings on: -behavioral health and self-management issues and interventions -tips for patients dealing with issues such as travel, surgery, and foot care -treating specific patient populations including Latinos, Native Americans, rural communities, and the uninsured -case studies from successful, replicable programs Also addressing the business aspects of diabetes care related to such areas as legal and regulatory issues and health policy initiatives, Handbook of Diabetes Management, brings you practical insights based on the latest research. "This handbook book by expert professionals covers every aspect of diabetic care. It is a sound, evidence-based, culturally informative, practical approach to diabetes prevention and disease management." -Kathleen Lambert, BSN, RN, JD, from the Foreword

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.

Heart failure is the biggest killer in the western world, and the prevalence is expected to increase due to aging of the population. Over the past decade there has been an increasing awareness of left ventricular (LV) diastolic dysfunction as a mechanism of congestive heart failure. This book provides the clinician with essential insights into the epidemiology and aetiology of diastolic heart failure, and will enable them to understand how the condition can be diagnosed. Furthermore, the book will provide insights in cardiac function that are needed to perform and interpret the diagnostic tests, and to provide some guides to treatment choices.

The cover of this book summarizes the central features of the sequestration hypothesis: Commonplace appearances seen in human coronary artery, fat stained in paraffin seetions by a new technique explained in Chapter Eleven, are arranged to suggest pathways of evolution toward atheroma. The hypothesis formulated and defended in the pages ofthis book is this: Fibroplasia progresses upward in column "a" from "la" to "3a" as a characteristic feature of aging. This starts sooner and progresses faster in men than in wornen. Numbers ofSMC's remain essentially constant so that fibroplasia per SMC steadily increases. The rise upward conveys an increasing propensity to sequester atherogenic lipids, causing transition rightward into column "b." Sequestered extracellular lipid then attracts fatty streak elements, especially foam cells and lyrnphocytes, to propel the arterial site rightward into column "c." Frame "lc" corresponds to the AHA Lesions Committee classification type IIb, the progression resistant fatty streak arising directly without prior lipid sequestration; this can progress to atheroma, but slowly after much delay, although extreme provocation can accelerate the process. Such progression is rightward toward atherorna with thin cap, not upward toward fibroplastic thickening. Frame "2c" corresponds to the AHA classification, type Ha, progression prone fatty streaks. These readily evolve into atheroma, again by horizontal progression.

Today, there are more than 23 million diabetics in the United States and with that number expected to rise drastically over the next decade the nation is faced with a health crisis of epidemic proportions. For those personally afflicted by this debilitating disease the everyday challenges can often seem overwhelming. In Diabetes and You, Dr. Naheed Ali offers both hope and empowerment to these sufferers and their families. Using the latest findings in clinical and physician studies, this book helps diabetics to successfully combat this disease and its symptoms on a number of fronts. Ali offers not only a hopeful perspective but also new and practical ways to confront and live with this condition. The full scope of diabetes-from its causes to its prevention and from the newest methods of treatment to the effects of diet and mental heath-is introduced in simple, non-technical language accessible to all readers. Diabetes and You is both state-of-the-art and user friendly, and emphasizes a whole body approach to this increasingly common, high-profile disease. As a physician and medical lecturer with a long association within the health care industry, Ali presents detailed advice to make coping with diabetes much simpler and easier than ever before. The reader is introduced to groundbreaking information on the risk factors associated with diabetes, the signs and symptoms, the different types of the disease, and how it can crop up in juvenile health. Diabetes and You will motivate diabetics to fight their condition in new and effective ways.

The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book 's primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

At a time of dramatic increases in the prevalence of obesity, it is appropriate that Type 2 diabetes has received a great deal of attention by the endocrinology community. Clearly, the management of insulin resistance and cardiovascular risk is a critical issue. However, it is important to also acknowledge and address Type 1 diabetes, whose prevalence is also increasing, and whose management remains complex. Currently it is estimated that 10-15% of those with diabetes carry the diagnosis of Type 1 diabetes, and frequently the diagnosis is not straightforward, as many clinicians recognize that more adults previously thought to have Type 2 diabetes actually have late-onset Type 1 diabetes (also termed latent autoimmune diabetes of the adult or LADA). Over the last decade tools for the management of Type 1 diabetes have also evolved; therefore, clinicians now have the opportunity to more closely replicate normal physiologic insulin secretion with either basal-bolus insulin therapy or continuous subcutaneous insulin infusions. While these advancements allow clinicians to manage patients with Type 1 diabetes better, they also add complexity to patient treatment. An updated text to address the concepts behind the recognition of new onset Type 1 diabetes in adults, the ongoing care of adults with established Type 1 diabetes, and future potential therapies and devices is warranted to review these issues for both endocrinologists and primary care providers with an interest in diabetes.
As part of the Oxford American Endocrinology Library, this volume stands as a concise guide in the treatment of Type 1 Diabetes in adults. The authors briefly examine the classification and pathophysiology of Type 1 diabetes (including predication and prevention and LADA) and address management (blood glucose monitoring, insulin therapy, and Continuous Subcutaneous Insulin Infusion) and complications (Hyperglycemia, Retinocpathy, Nephropathy, Neuropathy, etc) of the disease. Finally and perhaps most significantly, the authors consider "special situations" associated with Type 1 Diabetes patients, including inpatient treatment, pancreas and inslet transplantation, and how to treat pregnant and depressed patients and patients with eating disorders.

Over 20 million people in the United States have diabetes, a metabolic disorder characterized by the body's lack of production or ineffective use of insulin, and the rate is on the rise. Diabetes can cause acute, as well as long-term complications when not properly controlled. Some of the complications may include coma, cardiovascular disease, renal failure, blindness, nerve damage, vascular damage, and poor healing which can lead to amputation. Though there is no cure for either Type I or Type II diabetes, ongoing effort to develop new drug and gene therapies continues. In the meantime, the goals of treatment are disease management, prevention of complications, and improved quality of life. The choice of therapeutics varies by diabetes type and may depend on other significant factors. The selected regimen often includes medication, injection therapy, exercise and change in diet.
Over the past few decades, awareness of the importance of early diagnosis and treatment of diabetes has increased significantly. With approximately one-third of those affected by diabetes unaware of their illness, it is critical to make every effort to identify the disease early in its course. The primary care physician is frequently the first to see patients presenting with pre-diabetes and diabetes symptoms. This highly practical volume is specifically designed for primary care physicians and internists on the frontlines of care. It provides a clinically-focused roadmap to providing optimal care for patients with pre-diabetes and diabetes, from the initial patient visit through testing, goal-setting and follow-up care. It offers up-to-date information on diagnosis and treatment options for all types of diabetes, helping to expedite delivery of appropriate care.
Part of the new Oxford American Endocrinology Library, this concise yet comprehensive guide covers current approaches and new developments in the diagnosis, management and treatment of diabetes, including Type I, Type II, and gestational diabetes, as well as additional notes on pre-diabetes. The text covers new and emerging pharmacotherapies and complementary treatment guidelines, as well as valuable guidance on managing the major complications of diabetes. In addition to diet and exercise tips for patients, the guide also provides strategies and tools for inspiring healthier lifestyles and patient compliance to reach health goals.

This issue of Medical Clinics devoted to prediabetes and diabetes prevention belongs in the hands of every practicing internist, PCP, hospitalist, nurse practitioner, endocrinologist, and any healthcare provider who is concerned about the diabetes epidemic. The importance of this resides in our ability to prevent diabetes by early identification of individuals with a precursor condition termed prediabetes that affect 54 million adult Americans. This entity has grown globally over the recent decades paralleling the obesity epidemic. No country or region of the world is immune. Overweight and obesity affect approximately 60% of our population and children as well as adolescents are not spared. Approximately 13% of adolescents have prediabetes which has doubled since the year 2000. Both type 2 diabetes and prediabetes are preventable and reversible with lifestyle changes involving weight loss and exercise. This issue gives a historical perspective on diabetes prevention, examines its public health implications, and explores diabetes prevention initiatives. Essential topics covered include prediabetes definition, epidemiology, mechanisms of complications, pathophysiology, diagnosis, and treatment recommendations. Diabetes prevention trials and the economics of prevention are also covered.

The demands of caring for a child with diabetes can often become exhausting and overwhelming. Diabetes Distress and Burnout for Parents and Carers provides support to those caring for a child with type 1 diabetes. This booklet helps readers to identify the symptoms of burnout, understand what triggers them, and learn what steps they can take to improve their symptoms and build resilience. Featuring quotes from caregivers who have experienced and overcome burnout and practical tools to manage and ease the symptoms alongside guidance on what to do if a relapse occurs. In addition, the booklet highlights the support available and provides helpful links to sources and organisations where readers can go for further information on diabetes. An ideal resource for caregivers of children and young people with type 1 diabetes, as well as the wider diabetes healthcare team, including clinical psychologists, specialist nurses, endocrinologists and general practitioners.

The incidence and prevalence of type 2 diabetes mellitus have increased dramatically in modernized and developing nations over the past few decades. Thoroughly revised and expanded, this Second Edition responds to the epidemic and supplies a current overview and guide to the management of diabetes in the modern healthcare environment. This Second Edition offers a current perspective on diabetes demographics, epidemiology, pathophysiology, disease monitoring, and approaches to glucose control, and supplies new chapters by world-renowned experts on non-pharmacological management options, complications of the skin and urogenital function, related macrovascular conditions, coronary heart disease, stroke, and peripheral vascular disease, and rare forms of diabetes, PCOS, and NASH.

From America's most trusted health authority, this is the ultimate guide to managing Type 2 diabetes. Diabetes is a leading cause of death and disability in the U.S., and in recent years the disease has reached epidemic levels: nearly 19 million Americans now live with Type 2 diabetes and 13 million more are affected by its precursor, prediabetes. Now, at last, America's leading group of medical experts has created an easy-to-understand self-care reference to help people prevent and manage the disease. Authoritative and up to date, the book explains what diabetes is, describes its risk factors, and offers practical strategies for reducing those risks including improving nutrition, exercising more, and losing weight. For people who are currently living with diabetes, it offers comprehensive, helpful information about recommended lifestyle changes, blood-glucose testing, medications, alternative and complementary therapies, and how to prevent serious complications.Complete with special sections on gestational diabetes and the increasing numbers of American children who are at risk of developing Type 2 diabetes or who are living with it, this guide is an essential home reference for everyone with diabetes or prediabetes. The American Medical Association has been the leading group of medical experts in the United States and one of the most respected health-related organizations in the world for more than 150 years. Previous AMA books include the more than 2 million-copy bestseller, American Medical Association Family Medical Guide, now in its fourth edition (0-471-26911-5). Boyd E. Metzger, MD (Chicago, IL) is the Tom D. Spies Professor of Metabolism and Nutrition in the Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine at Northwestern University, Feinberg School of Medicine, and Attending Physician at Northwestern Memorial Hospital in Chicago. He headed Northwestern University's Clinical Center for the Type 2 Diabetes Prevention Program funded by the National Institute of Health

The management of diabetes in children and young people continues to develop in important areas, including self-monitoring, insulin delivery, dietary prescription, concept of control and the early identification of complications. Meanwhile responsibility for care has become a partnership between patients, parents and a multi-disciplinary team of health professionals. Key features of Childhood and Adolescent Diabetes include:

• Stand-alone chapters offering practical solutions to problems confronting children, young people and their parents
• Rational advice on monitoring and managing diabetic complications
• Guidance on the involvement of families, schools and teachers
• Discussion of the psychological aspects
• Recommendations on setting standards of care, audit, data-handling and registration
• Suggestions for setting up and running activities beyond the clinic

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

The enormous increase in our knowledge and understanding of diabetes mellitus in recent years has resulted in new management strategies for greatly enhancing care in diabetic pregnancy. Clinicians responsible for the care of women with diabetes need to keep abreast of these advances. Diabetes and Pregnancy: An International Approach to Diagnosis and Management is a comprehensive, yet practical guide to the present state of knowledge regarding diabetic pregnancy. It summarizes published literature, and offers clear and valuable information on the practicalities of providing special care before, during and after pregnancy. This volume will be indispensable to all members of the health care team involved in the care of pregnant diabetic women and their babies, including obstetricians, neonatologists, diabetes physicians, specialist nurses, midwives as well as general practitioners.

Dealing with Diabetes Burnout: How to Recharge and Get Back on Track When You Feel Frustrated and Overwhelmed Living with Diabetes is an inspiring and empowering guide to managing the daily work and pressure of diabetes management - counting carbohydrates at every meal, constantly adjusting medication doses, taking daily injections, pricking fingers multiple times a day, and struggling with the unavoidable challenges of fancy, yet imperfect, technology - that can lead to burnout. Vieira provides the tools and encouragement needed to help readers get back on track and make diabetes management a rewarding priority. Chapters directly address burnout in relation to: food, exercise, insulin dosing, blood sugar checking, fear of low blood sugar, being a caregiver/spouse of a person with diabetes, communicating more effectively with your doctor, taking a healthy ""vacation"" from diabetes, and creating realistic expectations and goals.

Discover how to manage diabetes for a healthier and happier life! Written for anyone diagnosed with type 2 diabetes (and for anyone who loves someone with diabetes), Managing Type 2 Diabetes For Dummies is an essential guide to understanding the effects of diabetes and knowing what steps to take to successfully manage this chronic illness. Diabetes can lead to serious complications but people with diabetes can control the condition and lower the risk of its many complications. This is your easy-to-understand guide that shows you how. Under the direction of The American Diabetes Association, Managing Type 2 Diabetes For Dummies gives hope to the one in 11 people in the United States who are affected by the disease. Written in simple-to-understand terms, Managing Type 2 Diabetes For Dummies is filled with a wealth of expert advice and includes the most current information on recent medical advances for treatment. Improperly managed diabetes and consistently high blood glucose levels can lead to serious diseases affecting the heart and blood vessels, eyes, kidneys, nerves, and teeth. With the authorities at the American Diabetes Association on your side, you will have a practical handbook for preventing complications and managing diabetes with confidence! Prevent and manage the complications of the disease Combat diabetes-related anxiety and depression Lead a healthy life with type 2 diabetes Tap into the better living "rules of the road" with Managing Type 2 Diabetes For Dummies. By modifying your diet, consulting with your doctors, staying active, and understanding what medications are right for you, you will be on the path to a happier and healthier lifestyle.

Self-manage digestive disorders through dietary choices

Suffering from a gastrointestinal disorder–whether it’s irritable bowel syndrome, gas, constipation, heartburn, or another condition–can be embarrassing and debilitating. While medical treatments and prescriptions can offer relief, one of the most important ways you can help yourself is to choose the right foods to eat.

Backed by the American Dietetic Association, this user-friendly guide shows you how to analyze your eating habits so that you can map out a dietary plan to manage and reduce the uncomfortable symptoms of digestive disorders. You’ll find practical recommendations for implementing changes in your lifestyle and advice on steering clear of common dietary mistakes. Your meals will be pleasurable and nourishing experiences–not painful ones–when you discover how to make the best and most comfortable food choices so you can embark on the road to digestive health.