Part of the Paediatric Psychology series Children and young people are increasingly among those being diagnosed with diabetes. However in the UK only 1 in 6 children succeed in controlling their diabetes successfully, despite support from parents and professionals. This enlightening new book is a comprehensive account of diabetes and the complex medical and psychosocial factors that influence metabolic control in children and young people. It presents a series of evidence-based and accessible educational, psychological and social approaches to increase specialist knowledge, promote positive attitudes, enhance patient care and create appropriate healthcare environments. The book offers an easy-to-comprehend approach to clinical care and includes practical tools for assessment for all healthcare professionals throughout the text. Featuring contributions from a number of international experts in the field, this thorough and wide-ranging guide is informative reading for all students, academics and professionals with an interest in paediatric psychology and health.

By 2030, diabetes will be the 7th leading cause of premature mortality worldwide, according to the World Health Organisation. The application of nanotechnology in medicine holds many possible advantages and over the past few decades, there has been huge progress in its utilisation. Nanotechnology is widely applied for cancer treatment and other diseases but, the use of it for diabetes treatment is now starting to flourish. This book presents the latest developments of nanomedicine for the treatment of different facets of diabetes and related disorders. With a multidisciplinary approach, chapters focus on previously overlooked topics in glucose sensing, insulin delivery and secretion, bioimaging and transplantation of islets. This book is suitable for researchers of nanomedicine, nanotechnology and diabetes looking into the emergence of new approaches for the treatment of this life-threatening disease.

Diabetes mellitus is a major global health problem. According to the most recent projections, the worldwide prevalence of diabetes mellitus is expected to reach 220 million in the year 2010 and 300 million in 2025 compared to the current prevalence of around 160 million.

This volume focuses on recent advances in the area of diabetes mellitus and its complications, from basic research at the molecular level to clinical medicine, spanning several areas including epidemiology, diagnosis, complications, prevention, treatment, beta cell function and dysfunction, metabolic syndrome, glucose and lipid metabolism and drug targets.

The international conference of which this is the proceedings provided a forum for the exchange of ideas and the dissemination of current knowledge about the full range of issues concerning type I and type II diabetes mellitus.

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As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Foot problems in diabetic patients are some of the most challenging complications to treat, due to an often quite late presentation of symptoms from the patient. Therefore visual recognition of presenting clinical signs is absolutely key for a successful diagnosis and subsequently, the right management programme.

The 3rd edition of Managing the Diabetic Foot once again provides a practical, handy and accessible pocket guide to the clinical management of patients with severe feet problems associated with diabetes, such as ulcers, infections and necrosis. By focusing on the need for a speedy response to the clinical signs, it will enable doctors make rapid, effective management decisions in order to help prevent deterioration and avoid the need for evental foot amputation.

Each chapter focuses specifically on the different stages of foot disease and the clinical management required at that particular stage, ie, the normal foot; high-risk foot, ulcerated foot, infected foot, necrotic foot and unsalvageable foot.Full colour throughout, it will feature over 150 clinical photos, numerous hints and tips to aid rapid-reference, as well as the latest national and international guidelines on diabetic foot management.Managing the Diabetic Foot, 3E, is the ideal go-to clinical tool for all diabetes professionals, specialist diabetes nurses and podiatrists managing patients with diabetic foot problems.

Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obesity epidemic and its relationship to cardiovascular disease. It provides an evidence-based approach to the topic, as well as emphasizes a combined treatment strategy for patients suffering from both obesity and cardiovascular disease.

Bioactive Food as Dietary Interventions for Diabetes, Second Edition is a valuable scientific resource that explores the latest advances in bioactive food research and the potential benefits of bioactive food choice on diabetic conditions. Written by experts from around the world, it presents important information that can help improve the health of those at risk for diabetes and diabetes related conditions using food selection as its foundation. This important resource for those involved in the dietary and nutritional care of diabetic patients is also ideal for researchers seeking information on alternative bioactive food-based solutions.

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians' offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

ABC of Diabetes provides primary care practitioners with a practical guide to all aspects of diabetes including the aetiology, diagnosis and management of Types 1 and 2 diabetes, detection and prevention, and the organization of care and support. Advances in diabetes care take place at a rapid rate and this new edition is updated throughout to cover the latest evidence-based information for contemporary practice. A new chapter describes the management of severe and complex obesity complicated by diabetes and the management of patients through bariatric surgery. It also covers the growing number of devices and digital technology, including health informatics, that can assist in diabetes care and provides evidence of their benefit. With more links to useful websites and resources online, it is now easier than ever to keep up-to-date with changes. Drawing on the professional and teaching experience of an expert author team, ABC of Diabetes is an essential guide for general practice, primary care practitioners, diabetes specialist nurses, as well as for medical students and those training in diabetes as a specialty.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

This monograph summarises the proceedings of the Seventh International Barts Symposium held 20 April 2001 in London, UK. Chapters address new developments in the administration of insulin, including oral preparations and long-acting insulin analogue. Breakthroughs in the understanding of the pathogenesis of type 2 diabetes are also covered, along with the future of the glitazones in management.

In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.

From the discovery of Pdx1, the first "master gene" of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.

This practical guide for teens with diabetes talks about issues specific to teens ages 16 to 19. It includes multiple no-nonsense tips that demonstrate how life with diabetes can be lived to the fullest. By identifying strategies to help manage high and low blood glucose and giving you ideas on how to get through the everyday drudge without giving up on your diabetes management, author Katherine Moran provides an essential source that is filled with informative and engaging photographs and illustrations, historical tidbits, and an index. Chapters cover using a meal plan and counting carbohydrates; understanding insulin therapy and oral medications; using physical activity to control glucose levels; dealing with other illnesses and preventing complications; being a safe and responsible driver; maintaining good health when traveling; overcoming peer pressure; and creating effective coping strategies for managing and living with diabetes. With the help of this book, teens will learn more about just what diabetes is, the treatment, how to handle the negative feelings it spans, and how to stay healthy and maintain an active life. Written in teen speak, Diabetes: The Ultimate Teen Guide, is a practical, hands-on guide that addresses the social and health issues specific to diabetic teens ages 16 to 19. Intended to empower teens to take control over the diabetes through effective disease management, they learn how to stay healthy and live life to the fullest-even with diabetes-through this no-nonsense guidance. Chapters cover using a meal plan and counting carbohydrates; understanding insulin therapy and oral medications; using physical activity to control glucose levels; dealing with other illnesses and preventing complications; being a safe and responsible driver; maintaining good health when traveling; overcoming peer pressure; and creating effective coping strategies for managing and living with diabetes. Filled with informative and engaging photographs and illustrations, historical tidbits, and a

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

Type 1 diabetes is a serious and common disease, afflicting one per 200 of the population worldwide. It is widely believed to cause harmful physical maldevelopment--congenital malformations--and other consequences in the unborn children of women with the disease. This book considers the history of the disease in pregnant women and this belief that it causes anomalies since the time of the discovery of insulin in 1921, and presents a profound and critical appraisal of the subject of its supposed prenatal harmfulness.

The human pancreas consists of two organs in one: the exocrine gland made up of pancreatic acinar cells and duct cells that produce digestive enzymes and sodium bicarbonate, respectively; the endocrine gland made up of four islet cells, namely alpha-, beta-, delta- and PP-cells that produce glucagon, insulin, somatostatin and pancreatic polypeptide, respectively. While the physiological role of exocrine p- creas is to secrete digestive enzyme responsible for our normal digestion, absorption and assimilation of nutrients, the endocrine pancreas is to secrete islet peptide h- mones maintaining our glucose homeostasis. The pancreatic functions are nely regulated by neurocrine, endocrine, paracrine and/or intracrine mechanisms. Thus, dysregulation of these pathways should have signi cant impacts on our health and disease. Nevertheless, the underlying mechanisms by which pancreatic functions are regulated remain poorly understood. Recent basic science and clinical studies con rm myriad physiological and pathophysiological roles of the tissue renin-angiotensin systems (RAS). Of parti- lar interest is the recent identi cation of a local and functional RAS in the pancreas, which in uences both its exocrine and endocrine function. Its role in the pat- genesis of pancreatic diseases including diabetes and pancreatitis is increasingly recognized, as is the therapeutic potential of RAS antagonism: RAS blockade l- its disease progression of type 2 diabetes mellitus and impaired glucose tolerance, and may also protect against pancreatic in ammation.

The twin epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to affect an ever increasing number of children, adolescents, and young adults. Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions. A unique guide on the subject, this volume provides clinical paradigms for diagnosis and management of pediatric T2DM and related conditions, while succinctly describing state-of-the-art basic and clinical sciences underlying these problems. The chapters in this volume are independent and concise. Each chapter focuses on a key clinical issue or mechanism of disease. Providing practical, data-driven resources based upon the totality of the evidence, this important text helps the reader understand the basics of pediatric obesity and T2DM and implement strategies to prevent and treat obesity and diabetes in children and adolescents. Management of Pediatric Obesity and Diabetes provides health professionals across many areas of research and practice with up-to-date, well-referenced, and comprehensive evidence on identification, treatment, and prevention of these chronic, serious, metabolic diseases in children. This volume will serve the reader as the most authoritative resource in the field to date.

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

This Handbook fulfils a pressing need within the area of psychological measurement in diabetes research and practice by providing access to material which has either been widely dispersed through the psychological and medical literature or has not previously been published.
Journal articles describing the psychometric development of scales have rarely included the scales themselves but this book includes copies of scales and a wealth of additional information from unpublished theses, reports and recent manuscripts.
You will find information about the reliability, validity, scoring, norms, and use of the measures in previous research presented in one volume.
The Handbook is designed to help researchers and clinicians:
. To select scales suitable for their purposes
. To administer and score the scales correctly
. To interpret the results appropriately.
Dr. Clare Bradley is Reader in Health Psychology and Director of the Diabetes Research Group at Royal Holloway, University of London.
Dr. Bradley and her research group have designed, developed and used a wide variety of measures of psychological processes and outcomes. Many of these measures have been designed and developed specifically for people with diabetes. Together with diabetes-specific psychological measures developed by other researchers internationally, these instruments have played an important part in facilitating patient-centred approaches to diabetes research and clinical practice.

Key Features * Details the latest diagnostic tests and treatments of diabetes and its complications, useful for ready reference by students, physicians, and healthcare professionals. * Explains how heart failure and stroke are deadly complications of diabetes along with kidney failure and life-threatening infections. * Establishes how cancer is linked to diabetes - a fact many people are not aware of - the book details the 6 types of cancer that may result from the disease, along with an individualized focus on the different "areas" of complications that occur from diabetes. * Discusses the effect of diabetes upon the minds of patients, in relation to depression, anxiety, panic, PTSD, eating disorders, delirium, and dementia.

Key Features Explains normal physiology of pregnancy in addition to the physiology, evaluation, and management of endocrine diseases in pregnancy, and in the pre- and post-partum periods. Explores from a clinical standpoint with practical applications, useful for students, residents, fellows, mid-level providers, and practicing physicians. Discusses special considerations and emerging topics including pregnancy in transgender men, obesity and metabolism, and endocrine emergencies.

Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease.

"Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms" is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy.

Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.